Small Angle X-Ray Scattering Studies In Structural Biology

4th annual SIBYLS bioSAXS workshop is ON!

Date: October 8-9, 2013 Location: Advance Light Source (ALS) at Lawrence Berkeley National Laboratory , Berkeley, CA

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Summary

The SIBYLS team will host a workshop with strong emphasis on experimental aspects of Small Angle X-ray Scattering techniques in structural biology. The two-day workshop will provide training on experimental techniques and software tutorial sessions primarily for biological SAXS studies. The latest advances in SAXS studies on biological systems will be reported and discussed by invited experts including our keynote speakers Prof. Peter Moore (Yale), Pau Bernando (CNRS France) and John Tainer (Scripps) (see program below). Also planned are presentations on solution structure modeling techniques for proteins, RNA, DNA-protein complexes. Second day of the workshop will be dedicated for processing of your own data previously collected at SIBYLS. Please contact Kevin Dyer kdyer@lbl.gov before you send the samples for the workshop.

Participants will receive updates on current software dedicated to analyze SAXS for structural biology:

Enrollment is limited to 30 participants. 



Organizers: Michal Hammel, Greg Hura, Robert Rambo



Inquires: Jane Tanamachi jtanamachi@lbl.gov

Registration: To attend the workshop you need register for the 2013 Advanced Light Source User Meeting. ALS user meeting will be held at Berkeley Lab October 7-9. Workshop will begin October 8th and continue through October 9th. When you registering, you must indicate “Small Angle X-Ray Scattering Studies In Structural Biology” as your workshop.

PROGRAM

October 8th LBNL Building 2 room 100b

11:30 Lunch at the ALS patio

12:45 Welcoming Remarks Michal Hammel

12:50 Peter Moore (Yale) “The Effects of Thermal Disorder on the Solution Scattering Profiles of Macromolecules”

13:30 John Tainer (Scripps, LBNL) “Bio-SAXS: linking quality controls to limit weaknesses and leverage strengths”

14:10 Yun-Xing Wang (NIH) “Combined use of SAXS, NMR and single molecule FRET to characterize RNA structures and conformation space “

14:50 Coffee Break

15:00 Pau Bernado ( CNRS - France) “Analysis of intrinsically disordered proteins by small-angle X-ray scattering”

15:40 Robert Rambo (LBNL) “Accurate assessment of mass, models, and resolution by SAXS.”

16:10 Dina Schneidman (UCSF) “Study of allosteric proteins with SAXS and modeling”

16:40 Susan Tsutakawa (LBNL) “Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA.”

October 9th LBNL Building 2 room 100b

9:00 Rob Rambo (LBNL) “Scatter: New software for SAXS data processing”

10:20 Coffee Break

10:40 Michal Hammel (LBNL) “FOXS-MES, BILBOMD, Allos-Mod FoXS”: New software for solution structure modeling”

12:00 Lunch Break at the ALS patio

Practical session with Mentors (Greg Hura, Rob Rambo and Michal Hammel)

13:00-14:50 Participating Students “Practical Session - Data reduction and processing with workshop participant data”

15:00 Coffee Break

15:30 -17:00 Student presentations or “What I learned at the bioSAXS workshop”