Recently in Science Highlights Category
As recently reported in the ALSNews:
“The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell’s DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.”
The original publication in Nature can be found here: K.C. Dong and J.M. Berger, “Structural basis for Gate-DNA recognition and bending by type IIA topoisomerases,” Nature 250, 1201 (2007).
At least 18 publications were made possible by the SIBYLS beamline in 2007 and have been added to our publications page. We are very pleased that the PX and SAXS endstations have been so useful to so many researchers doing such varied work. We hope that 2008 will be even more productive. If you know of any publications that we have not included please let us know.
In 2006 the Noller lab from the University of California, Santa Cruz solved the structure of the Thermus thermophilus 70S ribosome at 3.7Å resolution. This work was supported by data collected at both 12.3.1 and has been recently highlighted in the ALS news. The original publication was in CELL.
Korostelev A, Trakhanov S, Laurberg M, and Noller HF, “Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements.”
Cell 126, 1–13, September 22, 2006.
