Scott Classen: April 2010 Archives

Near and dear to our heart, Mre11, has been chosen as the May 2010 featured molecule by the Protein Structure Initiative. Additionally, the blurb on the PSI website features a beautiful rendering of the Pyrococcus furiosus and Thermotoga maritima Mre11 nucleases created by David Goodsell.

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UC Berkeley researchers, James Berger and Nathan Thomsen, used the SIBYLS beamline to solve the structure of a hexameric helicase, the Rho transcription termination factor (from E. coli), bound to both ATP mimics and an RNA substrate. The results showed that Rho functions like a rotary engine: as the motor spins, it pulls RNA strands through it’s interior. The rotary firing order of the motor is biased so that the Rho protein can walk in only one direction along the RNA chain. The results were published in the Oct 30th issue of Cell, and have recently been written up as an ALS scientific highlight.

Rho_hexhelicase.png

ALS Ring Status

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