Exploring the impact of nucleotide length on lipid nanoparticle structure and properties
Using SAXS, supported by cryo-EM, SIBYLS scientists along with researchers at Genentech gained insights into the impact of nucleotide length on lipid nanoparticle structure and properties. LNPs serve as a vital delivery platform for nucleic acid-based therapeutics. Their findings provide a crucial structural framework for the rational design and optimization of LNP formulations, guiding the development of more effective delivery systems for the increasingly diverse range of nucleic acid therapeutics.