Using SAXS, supported by cryo-EM, SIBYLS scientists along with researchers at Genentech gained insights into the impact of nucleotide length on lipid nanoparticle structure and properties. LNPs serve as a vital delivery platform for nucleic acid-based therapeutics. Their findings provide a crucial structural framework for the rational design and optimization of LNP formulations, guiding the…
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BilboMD is a web-based application developed and hosted by the SIBYLS beamline staff offering accessible pipelines for the analysis of SAXS data, including conformational sampling through molecular dynamics simulations, SAXS fitting with FoXS, and atomistic modeling. Additionally, the platform enables the direct integration of AlphaFold predictions into SAXS modeling workflows. Link to article.
In this publication led by Abigail Knight, an Assistant Professor of Chemistry at UNC-Chapel Hill and a SIBYLS SAXS user, the authors report on systematic research into amphiphilic polymer chelators, specifically examining how composition and patterning influence binding affinity and selectivity for rare earth elements (REEs). Using complementary dynamic light scattering (DLS) and small-angle X-ray…
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For this publication, the authors utilized SEC-SAXS data collected at SIBYLS beamline 12.3.1, along with SAXS model fitting, to confirm and further analyze the proteins of interest. Beamline scientist Michal Hammel and Postdoc Joshua Del Mundo played a vital role in the research. This work provides crucial mechanistic insights into spirochete-specific adaptations and their roles…
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The SIBYLS group (and Halbach award winners) enjoy a well-deserved day out kayaking at one of California’s largest protected coastal salt marshes which provides habitat for a fantastic diversity of birds, plants, marine mammals, and fish. The group was able to observe Southern Sea Otters, Harbor Seals and California Sea Lions in their natural habitat…
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We had a fantastic turnout for our one-day Zoom-based SAXS workshop, with 37 researchers from 25 unique labs across the U.S. in attendance. The user project session and the breakout rooms were particularly successful. During the user project session, five participants presented their research related to SAXS, which provided a great transition into the breakout…
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We are excited to announce a zoom-based SAXS workshop designed to help ensure the success of both past and future projects. This workshop is open to all researchers, from those with little or no SAXS experience to advanced users. The Advanced Light Source (ALS) will be open for three months, from October 14th to December…
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Dr. Gora presented this poster on Structure-Guided Ligand Discovery Under BRaVE Taskforce 5: A Multi-Lab Pipeline Against Emerging Viral Threats for the poster session at the 2025 ALS User Meeting on August 11.