Tautomeric form of C•A mismatch is stabilized by polymerase.

Using data collected at the SIBYLS beamline members of the Beese Lab have demonstrated that high fidelity polymerases can stabilize certain tautomeric forms of mismatched base pairs ultimately resulting in incorporation of mutations into the DNA duplex. >Even though high-fidelity polymerases copy DNA with remarkable accuracy, some base-pair mismatches are incorporated at low frequency, leading…
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