Beamline Publications

Are you about to publish a paper made possible by the SIBYLS beamline? If so we would greatly appreciate it if you would acknowledge the beamline, support staff, and our funding sources. This is critical in order for us to maintain SIBYLS beamline as a world class facility for SAXS and MX experiments.

This work was conducted at the Advanced Light Source (ALS), a national user facility operated by Lawrence Berkeley National Laboratory on behalf of the Department of Energy, Office of Basic Energy Sciences, through the Integrated Diffraction Analysis Technologies (IDAT) program, supported by DOE Office of Biological and Environmental Research. Additional support comes from the National Institute of Health project MINOS (R01GM105404) and a High-End Instrumentation Grant S10OD018483.

Additional acknowledgments to add if the manuscript is resulting from the SBDR P01 project.

Efforts to apply SAXS and crystallography to characterize eukaryotic pathways relevant to human cancers are supported in part by National Cancer Institute grant Structural Biology of DNA Repair (SBDR) CA92584.

If you received substantive help from beamline staff please also consider either adding them as a co-author or mentioning them in the acknowledgments.

Publications from the SIBYLS beamline have been tagged with convenient links to their respective PubMed entries link, and when applicable their entry in Faculty of 1000 link.


  1. Wallace BD, Berman Z, Mueller GA, Lin Y, Chang T, Andres SN, Wojtaszek JL, DeRose EF, Appel CD, London RE, Yan S, Williams RS. "APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress." Proc. Natl. Acad. Sci. U.S.A. 2016 Dec 27 link

  2. Arentson BW, Hayes EL, Zhu W, Singh H, Tanner JJ, Becker DF. "Engineering a trifunctional proline utilization A chimaera by fusing a DNA-binding domain to a bifunctional PutA." Biosci. Rep. 2016 Dec ;36(6)link

  3. Liu S, Street TO. "5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor." Protein Sci. 2016 Dec ;25(12)link

  4. Brosey CA, Ho C, Long WZ, Singh S, Burnett K, Hura GL, Nix JC, Bowman GR, Ellenberger T, Tainer JA. "Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor." Structure 2016 Nov 02 link

  5. Luo M, Gamage TT, Arentson BW, Schlasner KN, Becker DF, Tanner JJ. "Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function." J. Biol. Chem. 2016 Nov 11 ;291(46)link

  6. Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. "Structural basis for DNA recognition by STAT6." Proc. Natl. Acad. Sci. U.S.A. 2016 Nov 15 ;113(46)link

  7. Hammel M, Yu Y, Radhakrishnan SK, Chokshi C, Tsai MS, Matsumoto Y, Kuzdovich M, Remesh SG, Fang S, Tomkinson AE, Lees-Miller SP, Tainer JA. "An Intrinsically Disordered APLF Links Ku, DNA-PKcs and XRCC4-DNA Ligase IV in an Extended Flexible Non-Homologous End Joining Complex." J. Biol. Chem. 2016 Nov 14 link

  8. Keppel TR, Sarpong K, Murray EM, Monsey J, Zhu J, Bose R. "Biophysical Evidence for Intrinsic Disorder in the C-terminal Tails of the EGFR and HER3 Receptor Tyrosine Kinases." J. Biol. Chem. 2016 Nov 21 link

  9. Martin EW, Holehouse AS, Grace CR, Hughes A, Pappu RV, Mittag T. "Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation." J. Am. Chem. Soc. 2016 Nov 30 ;138(47)link

  10. Araya-Secchi R, Neel BL, Sotomayor M. "An elastic element in the protocadherin-15 tip link of the inner ear." Nat Commun 2016 Nov 18 ;7link

  11. Liu LK, Abdelwahab H, Martin Del Campo JS, Mehra-Chaudhary R, Sobrado P, Tanner JJ. "The Structure of the Antibiotic Deactivating, N-hydroxylating Rifampicin Monooxygenase." J. Biol. Chem. 2016 Oct 07 ;291(41)link

  12. Schulze-Gahmen U, Echeverria I, Stjepanovic G, Bai Y, Lu H, Schneidman-Duhovny D, Doudna JA, Zhou Q, Sali A, Hurley JH. "Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex." Elife 2016 Oct 12 ;5link

  13. Johnson PM, Gucinski GC, Garza-Sánchez F, Wong T, Hung LW, Hayes CS, Goulding CW. "Functional Diversity of Cytotoxic tRNase/Immunity Protein Complexes from Burkholderia pseudomallei." J. Biol. Chem. 2016 Sep 9 ;291(37):19387-400 link

  14. Schiffer JM, Malmstrom RD, Parnell J, Ramirez-Sarmiento C, Reyes J, Amaro RE, Komives EA. "Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer." Structure 2016 Aug 2 ;24(8):1248-56 link

  15. Yachnin BJ, Lau PC, Berghuis AM. "The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure." Biochim. Biophys. Acta 2016 Aug 26 ;1864(12):1641-1648 link

  16. Bhowmick A, Brookes DH, Yost SR, Dyson HJ, Forman-Kay JD, Gunter D, Head-Gordon M, Hura GL, Pande VS, Wemmer DE, Wright PE, Head-Gordon T. "Finding Our Way in the Dark Proteome." J. Am. Chem. Soc. 2016 Aug 10 ;138(31):9730-42 link

  17. Nikolaienko RM, Hammel M, Dubreuil V, Zalmai R, Hall DR, Mehzabeen N, Karuppan SJ, Harroch S, Stella SL, Bouyain S. "Structural Basis for Interactions Between Contactin Family Members and Protein Tyrosine Phosphatase Receptor Type G in Neural Tissues." J. Biol. Chem. 2016 Aug 18 link

  18. Gilmore SF, Blanchette CD, Scharadin TM, Hura GL, Rasley A, Corzett M, Pan CX, Fischer NO, Henderson PT. "Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake." ACS Appl Mater Interfaces 2016 Aug 17 ;8(32):20549-57 link

  19. Horvath MP, George EW, Tran QT, Baumgardner K, Zharov G, Lee S, Sharifzadeh H, Shihab S, Mattinson T, Li B, Bernstein PS. "Structure of the lutein-binding domain of human StARD3 at 1.74 Å resolution and model of a complex with lutein." Acta Crystallogr F Struct Biol Commun 2016 Aug 1 ;72(Pt 8):609-18 link

  20. Riccio AA, McCauley M, Langelier MF, Pascal JM. "Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling." Structure 2016 Aug 3 link

  21. Chu J, Oh Y, Sens A, Ataie N, Dana H, Macklin JJ, Laviv T, Welf ES, Dean KM, Zhang F, Kim BB, Tang CT, Hu M, Baird MA, Davidson MW, Kay MA, Fiolka R, Yasuda R, Kim DS, Ng HL, Lin MZ. "A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo." Nat. Biotechnol. 2016 Jul ;34(7):760-7 link

  22. Bale JB, Gonen S, Liu Y, Sheffler W, Ellis D, Thomas C, Cascio D, Yeates TO, Gonen T, King NP, Baker D. "Accurate design of megadalton-scale two-component icosahedral protein complexes." Science 2016 Jul 22 ;353(6297):389-94 link

  23. Hammel M, Amlanjyoti D, Reyes FE, Chen JH, Parpana R, Tang HY, Larabell CA, Tainer JA, Adhya S. "HU multimerization shift controls nucleoid compaction." Sci Adv 2016 Jul ;2(7):e1600650 link

  24. Schneidman-Duhovny D, Hammel M, Tainer JA, Sali A. "FoXS, FoXSDock and MultiFoXS: Single-state and multi-state structural modeling of proteins and their complexes based on SAXS profiles." Nucleic Acids Res. 2016 Jul 8 ;44(W1):W424-9 link

  25. Sivá M, Svoboda M, Veverka V, Trempe JF, Hofmann K, Kožíšek M, Hexnerová R, Sedlák F, Belza J, Brynda J, Šácha P, Hubálek M, Starková J, Flaisigová I, Konvalinka J, Šašková KG. "Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog." Sci Rep 2016 ;6:30443 link

  26. Aydin H, Sultana A, Li S, Thavalingam A, Lee JE. "Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex." Nature 2016 Jun 23 ;534(7608):562-5 link

  27. Chen E, Salinas ND, Huang Y, Ntumngia F, Plasencia MD, Gross ML, Adams JH, Tolia NH. "Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein." Proc. Natl. Acad. Sci. U.S.A. 2016 May 31 ;113(22):6277-82 link

  28. Boyken SE, Chen Z, Groves B, Langan RA, Oberdorfer G, Ford A, Gilmore JM, Xu C, DiMaio F, Pereira JH, Sankaran B, Seelig G, Zwart PH, Baker D. "De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity." Science 2016 May 6 ;352(6286):680-7 link

  29. Das RK, Huang Y, Phillips AH, Kriwacki RW, Pappu RV. "Cryptic sequence features within the disordered protein p27Kip1 regulate cell cycle signaling." Proc. Natl. Acad. Sci. U.S.A. 2016 May 17 ;113(20):5616-21 link

  30. Youngblut MD, Tsai CL, Clark IC, Carlson HK, Maglaqui AP, Gau-Pan PS, Redford SA, Wong A, Tainer JA, Coates JD. "Perchlorate Reductase Is Distinguished by Active Site Aromatic Gate Residues." J. Biol. Chem. 2016 Apr 22 ;291(17):9190-202 link

  31. Hodge CD, Ismail IH, Edwards RA, Hura GL, Xiao AT, Tainer JA, Hendzel MJ, Glover JN. "RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment." J. Biol. Chem. 2016 Apr 29 ;291(18):9396-410 link

  32. Brooun A, Gajiwala KS, Deng YL, Liu W, Bolaños B, Bingham P, He YA, Diehl W, Grable N, Kung PP, Sutton S, Maegley KA, Yu X, Stewart AE. "Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance." Nat Commun 2016 ;7:11384 link

  33. Hilario E, Caulkins BG, Huang YM, You W, Chang CE, Mueller LJ, Dunn MF, Fan L. "Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water." Biochim. Biophys. Acta 2016 Mar ;1864(3):268-79 link

  34. Melchior JT, Walker RG, Morris J, Jones MK, Segrest JP, Lima DB, Carvalho PC, Gozzo FC, Castleberry M, Thompson TB, Davidson WS. "An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding." J. Biol. Chem. 2016 Mar 4 ;291(10):5439-51 link

  35. Militi S, Maywood ES, Sandate CR, Chesham JE, Barnard AR, Parsons MJ, Vibert JL, Joynson GM, Partch CL, Hastings MH, Nolan PM. "Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking." Proc. Natl. Acad. Sci. U.S.A. 2016 Mar 8 ;113(10):2756-61 link

  36. Duffy CM, Hilbert BJ, Kelch BA. "A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site." J. Mol. Biol. 2016 Mar 27 ;428(6):1023-40 link

  37. Edeling MA, Diamond MS, Fremont DH. "Structural basis of Flavivirus NS1 assembly and antibody recognition." Proc. Natl. Acad. Sci. U.S.A. 2014 Mar 18 ;111(11):4285-90 link

  38. Chaudhury P, Neiner T, D'Imprima E, Banerjee A, Reindl S, Ghosh A, Arvai AS, Mills DJ, van der Does C, Tainer JA, Vonck J, Albers SV. "The nucleotide-dependent interaction of FlaH and FlaI is essential for assembly and function of the archaellum motor." Mol. Microbiol. 2016 Feb ;99(4):674-85 link

  39. Chen M, Chou WK, Toyomasu T, Cane DE, Christianson DW. "Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase." ACS Chem. Biol. 2016 Apr 15 ;11(4):889-99 link

  40. Woods RD, O'Shea VL, Chu A, Cao S, Richards JL, Horvath MP, David SS. "Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases." Nucleic Acids Res. 2016 Jan 29 ;44(2):801-10 link


  1. Brunette TJ, Parmeggiani F, Huang PS, Bhabha G, Ekiert DC, Tsutakawa SE, Hura GL, Tainer JA, Baker D. "Exploring the repeat protein universe through computational protein design." Nature 2015 Dec 24 ;528(7583):580-4 link

  2. Eustermann S, Wu WF, Langelier MF, Yang JC, Easton LE, Riccio AA, Pascal JM, Neuhaus D. "Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1." Mol. Cell 2015 Dec 3 ;60(5):742-54 link

  3. Dawicki-McKenna JM, Langelier MF, DeNizio JE, Riccio AA, Cao CD, Karch KR, McCauley M, Steffen JD, Black BE, Pascal JM. "PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain." Mol. Cell 2015 Dec 3 ;60(5):755-68 link

  4. Fields JB, Hollingsworth SA, Chreifi G, Heyden M, Arce AP, Magaña-Garcia HI, Poulos TL, Tobias DJ. ""Bind and Crawl" Association Mechanism of Leishmania major Peroxidase and Cytochrome c Revealed by Brownian and Molecular Dynamics Simulations." Biochemistry 2015 Dec 15 ;54(49):7272-82 link

  5. Harris GG, Lombardi PM, Pemberton TA, Matsui T, Weiss TM, Cole KE, Köksal M, Murphy FV, Vedula LS, Chou WK, Cane DE, Christianson DW. "Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence." Biochemistry 2015 Dec 08 ;54(48)link

  6. Suslov NB, DasGupta S, Huang H, Fuller JR, Lilley DM, Rice PA, Piccirilli JA. "Crystal structure of the Varkud satellite ribozyme." Nat. Chem. Biol. 2015 Nov ;11(11):840-6 link

  7. Wuerth ME, Cragerud RK, Clint Spiegel P. "Structure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody." Sci Rep 2015 ;5:17216 link

  8. Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z. "Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2)." J. Biol. Chem. 2015 Nov 6 ;290(45):27261-70 link

  9. Pratt AJ, DiDonato M, Shin DS, Cabelli DE, Bruns CK, Belzer CA, Gorringe AR, Langford PR, Tabatabai LB, Kroll JS, Tainer JA, Getzoff ED. "Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus." J. Bacteriol. 2015 Dec 15 ;197(24):3834-47 link

  10. Sauvé V, Lilov A, Seirafi M, Vranas M, Rasool S, Kozlov G, Sprules T, Wang J, Trempe JF, Gehring K. "A Ubl/ubiquitin switch in the activation of Parkin." EMBO J. 2015 Oct 14 ;34(20)link

  11. Musayev FN, Zarate-Perez F, Bardelli M, Bishop C, Saniev EF, Linden RM, Henckaerts E, Escalante CR. "Structural Studies of AAV2 Rep68 Reveal a Partially Structured Linker and Compact Domain Conformation." Biochemistry 2015 Sep 29 ;54(38):5907-19 link

  12. Remesh SG, Santosh V, Escalante CR. "Structural Studies of IRF4 Reveal a Flexible Autoinhibitory Region and a Compact Linker Domain." J. Biol. Chem. 2015 Sep 24 link

  13. Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M. "T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26." Nat. Immunol. 2015 Sep ;16(9):970-9 link

  14. Brehove M, Wang T, North J, Luo Y, Dreher SJ, Shimko JC, Ottesen JJ, Luger K, Poirier MG. "Histone Core Phosphorylation Regulates DNA Accessibility." J. Biol. Chem. 2015 Sep 11 ;290(37):22612-21 link

  15. Luo M, Tanner JJ. "Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1." Biochemistry 2015 Sep 8 ;54(35):5513-22 link

  16. Tsai CL, Williams GJ, Perry JJ, Tainer JA. "An AAA+ ATPase Clamshell Targets Transposition." Cell 2015 Aug 13 ;162(4):701-3 link

  17. He W, Scharadin TM, Saldana M, Gellner C, Hoang-Phou S, Takanishi C, Hura GL, Tainer JA, Carraway Iii KL, Henderson PT, Coleman MA. "Cell-free expression of functional receptor tyrosine kinases." Sci Rep 2015 ;5:12896 link

  18. Lin L, Gopal S, Sharda A, Passam F, Bowley SR, Stopa J, Xue G, Yuan C, Furie BC, Flaumenhaft R, Huang M, Furie B. "Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b'x Domain." J. Biol. Chem. 2015 Sep 25 ;290(39):23543-52 link

  19. Behera RK, Torres R, Tosha T, Bradley JM, Goulding CW, Theil EC. "Fe(2+) substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization." J. Biol. Inorg. Chem. 2015 Sep ;20(6)link

  20. Schumacher MA, Tonthat NK, Lee J, Rodriguez-Castañeda FA, Chinnam NB, Kalliomaa-Sanford AK, Ng IW, Barge MT, Shaw PL, Barillà D. "Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages." Science 2015 Sep 04 ;349(6252)link

  21. Fan H, Hahm J, Diggs S, Perry JJ, Blaha G. "Structural and Functional Analysis of BipA, a Regulator of Virulence in Enteropathogenic Escherichia coli." J. Biol. Chem. 2015 Aug 21 ;290(34):20856-64 link

  22. Gupta K, Martin R, Sharp R, Sarachan KL, Ninan NS, Van Duyne GD. "Oligomeric Properties of Survival Motor Neuron·Gemin2 Complexes." J. Biol. Chem. 2015 Aug 14 ;290(33):20185-99 link

  23. Zhang ZM, Liu S, Lin K, Luo Y, Perry JJ, Wang Y, Song J. "Crystal Structure of Human DNA Methyltransferase 1." J. Mol. Biol. 2015 Jul 31 ;427(15):2520-31 link

  24. Tan TC, Kracher D, Gandini R, Sygmund C, Kittl R, Haltrich D, Hällberg BM, Ludwig R, Divne C. "Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation." Nat Commun 2015 ;6:7542 link

  25. Hilbert BJ, Hayes JA, Stone NP, Duffy CM, Sankaran B, Kelch BA. "Structure and mechanism of the ATPase that powers viral genome packaging." Proc. Natl. Acad. Sci. U.S.A. 2015 Jul 21 ;112(29):E3792-9 link

  26. Hodge CD, Edwards RA, Markin CJ, McDonald D, Pulvino M, Huen MS, Zhao J, Spyracopoulos L, Hendzel MJ, Glover JN. "Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting." ACS Chem. Biol. 2015 Jul 17 ;10(7):1718-28 link

  27. Kukshal V, Kim IK, Hura GL, Tomkinson AE, Tainer JA, Ellenberger T. "Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining." Nucleic Acids Res. 2015 Aug 18 ;43(14):7021-31 link

  28. Tsutakawa SE, Tainer JA. "Bending Forks and Wagging Dogs--It's about the DNA 3' Tail." Mol. Cell 2015 Jun 18 ;58(6):972-3 link

  29. Ihms EC, Foster MP. "MESMER: minimal ensemble solutions to multiple experimental restraints." Bioinformatics 2015 Jun 15 ;31(12):1951-8 link

  30. Wasserman MR, Pulk A, Zhou Z, Altman RB, Zinder JC, Green KD, Garneau-Tsodikova S, Doudna Cate JH, Blanchard SC. "Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions." Nat Commun 2015 ;6:7896 link

  31. Chen X, Kim IK, Honaker Y, Paudyal SC, Koh WK, Sparks M, Li S, Piwnica-Worms H, Ellenberger T, You Z. "14-3-3 proteins restrain the Exo1 nuclease to prevent overresection." J. Biol. Chem. 2015 May 8 ;290(19):12300-12 link

  32. Banerjee A, Tsai CL, Chaudhury P, Tripp P, Arvai AS, Ishida JP, Tainer JA, Albers SV. "FlaF Is a β-Sandwich Protein that Anchors the Archaellum in the Archaeal Cell Envelope by Binding the S-Layer Protein." Structure 2015 May 5 ;23(5):863-72 link

  33. Pascal JM, Ellenberger T. "The rise and fall of poly(ADP-ribose): An enzymatic perspective." DNA Repair (Amst.) 2015 Aug ;32:10-6 link

  34. Rambo RP, Tainer JA. "Modeling macromolecular motions by x-ray-scattering-constrained molecular dynamics." Biophys. J. 2015 May 19 ;108(10):2421-3 link

  35. Tang W, Li H, Doud EH, Chen Y, Choing S, Plaza C, Kelleher NL, Poulos TL, Silverman RB. "Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid." J. Am. Chem. Soc. 2015 May 13 ;137(18):5980-9 link

  36. Köfinger J, Ragusa MJ, Lee IH, Hummer G, Hurley JH. "Solution structure of the Atg1 complex: implications for the architecture of the phagophore assembly site." Structure 2015 May 5 ;23(5):809-18 link

  37. Topolska-Woś AM, Shell SM, Kilańczyk E, Szczepanowski RH, Chazin WJ, Filipek A. "Dimerization and phosphatase activity of calcyclin-binding protein/Siah-1 interacting protein: the influence of oxidative stress." FASEB J. 2015 May ;29(5)link

  38. Tsutakawa SE, Yan C, Xu X, Weinacht CP, Freudenthal BD, Yang K, Zhuang Z, Washington MT, Tainer JA, Ivanov I. "Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response." Structure 2015 Apr 7 ;23(4):724-33 link

  39. Tainer JA. "Dynamic structures in DNA damage responses & cancer." Prog. Biophys. Mol. Biol. 2015 Mar ;117(2-3):129-33 link

  40. McMillan BJ, Schnute B, Ohlenhard N, Zimmerman B, Miles L, Beglova N, Klein T, Blacklow SC. "A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases." Mol. Cell 2015 Mar 5 ;57(5):912-24 link

  41. Walker RG, Angerman EB, Kattamuri C, Lee YS, Lee SJ, Thompson TB. "Alternative binding modes identified for growth and differentiation factor-associated serum protein (GASP) family antagonism of myostatin." J. Biol. Chem. 2015 Mar 20 ;290(12):7506-16 link

  42. Cai F, Dou Z, Bernstein SL, Leverenz R, Williams EB, Heinhorst S, Shively J, Cannon GC, Kerfeld CA. "Advances in Understanding Carboxysome Assembly in Prochlorococcus and Synechococcus Implicate CsoS2 as a Critical Component." Life (Basel) 2015 Mar 27 ;5(2)link

  43. Andres SN, Appel CD, Westmoreland JW, Williams JS, Nguyen Y, Robertson PD, Resnick MA, Williams RS. "Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair." Nat. Struct. Mol. Biol. 2015 Feb ;22(2):158-66 link

  44. Schumacher MA, Chinnam NB, Cuthbert B, Tonthat NK, Whitfill T. "Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis." Genes Dev. 2015 Feb 15 ;29(4):451-64 link

  45. Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE, Saphire EO. "Structural basis for marburg virus neutralization by a cross-reactive human antibody." Cell 2015 Feb 26 ;160(5):904-12 link

  46. Fuss JO, Tsai CL, Ishida JP, Tainer JA. "Emerging critical roles of Fe-S clusters in DNA replication and repair." Biochim. Biophys. Acta 2015 Jun ;1853(6):1253-71 link

  47. Cheguru P, Majumder A, Yadav R, Gopalakrishna KN, Gakhar L, Artemyev NO. "The solution structure of the transducin-α-uncoordinated 119 protein complex suggests occlusion of the Gβ₁γ₁-binding sites." FEBS J. 2015 Feb ;282(3)link

  48. White MR, Khan MM, Deredge D, Ross CR, Quintyn R, Zucconi BE, Wysocki VH, Wintrode PL, Wilson GM, Garcin ED. "A dimer interface mutation in glyceraldehyde-3-phosphate dehydrogenase regulates its binding to AU-rich RNA." J. Biol. Chem. 2015 Jan 16 ;290(3):1770-85 link

  49. Lafrance-Vanasse J, Williams GJ, Tainer JA. "Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair." Prog. Biophys. Mol. Biol. 2015 Jan 7 link


  1. Muia J, Zhu J, Gupta G, Haberichter SL, Friedman KD, Feys HB, Deforche L, Vanhoorelbeke K, Westfield LA, Roth R, Tolia NH, Heuser JE, Sadler JE. "Allosteric activation of ADAMTS13 by von Willebrand factor." Proc. Natl. Acad. Sci. U.S.A. 2014 Dec 30 ;111(52)link

  2. Partridge JR, Lavery LA, Elnatan D, Naber N, Cooke R, Agard DA. "A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity." Elife 2014 ;3link

  3. Reyes FE, Schwartz CR, Tainer JA, Rambo RP. "Methods for using new conceptual tools and parameters to assess RNA structure by small-angle X-ray scattering." Meth. Enzymol. 2014 ;549:235-63 link

  4. Lai YT, Reading E, Hura GL, Tsai KL, Laganowsky A, Asturias FJ, Tainer JA, Robinson CV, Yeates TO. "Structure of a designed protein cage that self-assembles into a highly porous cube." Nat Chem 2014 Dec ;6(12):1065-71 link

  5. Kim SJ, Fernandez-Martinez J, Sampathkumar P, Martel A, Matsui T, Tsuruta H, Weiss TM, Shi Y, Markina-Inarrairaegui A, Bonanno JB, Sauder JM, Burley SK, Chait BT, Almo SC, Rout MP, Sali A. "Integrative structure-function mapping of the nucleoporin Nup133 suggests a conserved mechanism for membrane anchoring of the nuclear pore complex." Mol. Cell Proteomics 2014 Nov ;13(11):2911-26 link

  6. Peng Y, Lu J, Wong JJ, Edwards RA, Frost LS, Mark Glover JN. "Mechanistic basis of plasmid-specific DNA binding of the F plasmid regulatory protein, TraM." J. Mol. Biol. 2014 Nov 11 ;426(22):3783-95 link

  7. Pratt AJ, Shin DS, Merz GE, Rambo RP, Lancaster WA, Dyer KN, Borbat PP, Poole FL, Adams MW, Freed JH, Crane BR, Tainer JA, Getzoff ED. "Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes." Proc. Natl. Acad. Sci. U.S.A. 2014 Oct 14 link

  8. Luo M, Christgen S, Sanyal N, Arentson BW, Becker DF, Tanner JJ. "Evidence That the C-Terminal Domain of a Type B PutA Protein Contributes to Aldehyde Dehydrogenase Activity and Substrate Channeling." Biochemistry 2014 Sep 9 ;53(35):5661-73 link

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