Month: June 2009

Structure and Flexibility Within Proteins as Identified Through SAXS

In a recent article in the General Physiology and Biophysics we describe an analysis tool using relatively inexpensive small angle X-ray scattering (SAXS) measurements to identify protein flexibility and validate a constructed minimal ensemble of models, which represent highly populated conformations in solution. The resolution of these results is sufficient to address the questions being…
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Flipping of Alkylated DNA Damage Bridges Base and Nucleotide Excision Repair

Julie Tubbs from John Tainer’s group at Scripps published a totally sweet paper in the June 11, 2009 issue of Nature demonstrating that the ATL protein uses nucleotide flipping to link alkylated base damage to the nucleotide excision repair pathway. This publication was in part made possible by the SIBYLS beamline.  Abstract: Alkyltransferase-like proteins (ATLs) share…
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