Wen Zhang and Jack Dunkle in the Cate lab have a nice report out in the August 21, 2009 issue of Science describing their latest crystal structures of the E. coli ribosome with and without tRNA mimcs. These new structure shed light on the rachet-like action of the intact ribosome as it interacts with tRNA…
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Cover Illustration from the September 2009 issue of RNA: Crystal structure of the lysine riboswitch bound to lysine (Protein Data Bank code: 3d0u) Image details show RNA: ribbon; lysine: space-filling representation, red; iridium hexamine ions: space-filling representation, blue. Abstract: Riboswitches are metabolite-sensitive elements found in mRNAs that control gene expression through a regulatory secondary structural…
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In this paper, published in Nucleic Acid Research, the authors used small-angle X-ray scattering (SAXS) combined with advanced computational approaches to characterize the conformational variability and DNA-binding properties of PNK. Extensive use of the SAXS capabilities of the SIBYLS beamline allowed the authors to visualize a flexible attachment of the FHA domain to the catalytic…
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