Month: May 2013

Comprehensive macromolecular conformations mapped by quantitative SAXS analyses

SIBYLS scientists have recently published and made available tools for generating [SAXS structural comparison maps](/saxs_similarity “SAXS structural comparison maps”). Details of the methods have been published in Nature Methods. >Biological macromolecular functions require distinct conformational states that are challenging to examine comprehensively. Current methods to quantify conformational similarities and distinguish different assembly states are underdeveloped.…
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Super-Resolution in Solution X-Ray Scattering and Its Applications to Structural Systems Biology

Rob and John have a new review on SAXS and its application to systems biology published in the Annual Review of Biophysics. See if you can spot the musical theme. >Small-angle X-ray scattering (SAXS) is a robust technique for the comprehensive structural characterizations of biological macromolecular complexes in solution. Here, we present a coherent synthesis…
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