RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles

In this study, the authors present structures and functional analyses for the RAD51C-XRCC3 tumor suppressor complex, providing insights into recurrent mutations in cancer and Fanconi Anemia patients that uncover distinct DNA replication fork protection, restart and reversal regions. The publication was highlighted as a Featured Article by Nature Communications. Structural data for this publication were collected at both beamline 8.3.1 and the SIBYLS beamline (12.3.1)