SIBYLS SAXS Workshop
Save the date! SIBYLS will be holding a SAXS workshop during the ALS User meeting from August 25-27, 2020. Details about the workshop coming soon. You can find general information about the User Meeting on the ALS website.
Designing and defining dynamic protein cage nanoassemblies in solution
Central challenges in the design of large and dynamic macromolecular assemblies for synthetic biology lie in developing effective methods for testing design strategies and their outcomes, including comprehensive assessments of solution behavior. The authors of this paper created and validated an advanced design of a 600-kDa protein homododecamer that self-assembles into a symmetric tetrahedral cage.…
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Postdoctoral position open with the SIBYLS group at the Advanced Light Source
Are you looking to apply your skills in Integrative Structural Biology to the development of new approaches to explore organization of functional bacterial chromosome? The SIBYLS Group at Lawrence Berkeley National Laboratory is seeking a Biochemist Postdoctoral Fellow in the field of Integrative Structural Biology. For more details on the position and to apply follow…
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Formation of repressive complex in the mammalian circadian clock is demoted by the secondary pocket of CRY1
In this paper, the authors show that CRY1, a protein coding gene that activates circadian gene expression and metabolic states and circadian oscillators, binds directly to the PAS domain core of CLOCK:BMAL1. Precise control of CLOCK:BMAL1 activity by coactivators and repressors establishes the ~24 hr periodicity of gene expression. Integrative modeling and solution X-ray scattering…
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SAXS used to elucidate mechanism of inner-ear mechanotransduction
Tip link filaments convey force and gate inner-ear hair-cell transduction channels to mediate perception of sound and head movements. Cadherin-23 and protocadherin-15 form tip links through a calcium-dependent interaction of their extracellular domains made of multiple extracellular cadherin (EC) repeats. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved…
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7th Annual SIBYLS BioSAXS workshop 2016
We are pleased to announce the 7th annual SIBYLS bioSAXS workshop: **Date**: October 4th – 5th, 2016 **Location**: Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory, Berkeley, CA **Description**: The 7th annual SIBYLS bioSAXS workshop will cover frontiers in Biological SAXS. The two-day workshop will provide participants with software tutorial sessions for biological SAXS…
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SIBYLS Installs New Dectris Detector
Our new pixel array detector, a [Pilatus3 2M](https://www.dectris.com/PILATUS3_SandX.html#main_head_navigation) from dectris, arrived at LBNL on July 27, 2015 and was installed on the SAXS endstation at SIBYLS beamline 12.3.1. The first user data was collected on August 19, 2015.
2015 SAXS Hands-on Workshop a Success
Our 6th annual SIBYLS bioSAXS workshop “Frontiers in biological SAXS” was a huge success. A big thank you to all of you who attended and a special thanks to our fabulous speakers: – Robert Rambo, Principal Beamline Scientist for the solution state SAXS beamline B21 at the Diamond Light Source, Oxfordshire, UK – John J.…
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