Beamline Publications

Are you about to publish a paper made possible by the SIBYLS beamline? If so we would greatly appreciate it if you would acknowledge the beamline, support staff, and our funding sources. This is critical in order for us to maintain SIBYLS beamline as a world class facility for SAXS and MX experiments.

  • This work was conducted at the Advanced Light Source (ALS), a national user facility operated by Lawrence Berkeley National Laboratory on behalf of the Department of Energy, Office of Basic Energy Sciences, through the Integrated Diffraction Analysis Technologies (IDAT) program, supported by DOE Office of Biological and Environmental Research. Additional support comes from the National Institute of Health project ALS-ENABLE (P30 GM124169) and a High-End Instrumentation Grant S10OD018483.
  • Additional acknowledgments to add if the manuscript is resulting from the SBDR P01 project.

    Efforts to apply SAXS and crystallography to characterize eukaryotic pathways relevant to human cancers are supported in part by National Cancer Institute grant Structural Biology of DNA Repair (SBDR) CA92584.

    If you received substantive help from beamline staff please also consider either adding them as a co-author or mentioning them in the acknowledgments.

    Publications from the SIBYLS beamline have been tagged with convenient links to their respective PubMed entries link, and when applicable their entry in Faculty of 1000 link.


    1. Stachowski TR, Snell ME, Snell EH. "A SAXS-based approach to rationally evaluate radical scavengers - toward eliminating radiation damage in solution and crystallographic studies." Journal of synchrotron radiation 2021 Sep 01 ;28(Pt 5):1309-1320 link

    2. Lees-Miller JP, Cobban A, Katsonis P, Bacolla A, Tsutakawa SE, Hammel M, Meek K, Anderson DW, Lichtarge O, Tainer JA, Lees-Miller SP. "Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease." Progress in biophysics and molecular biology 2021 Aug ;163:87-108 link

    3. Ueda G, Antanasijevic A, Fallas JA, Sheffler W, Copps J, Ellis D, Hutchinson GB, Moyer A, Yasmeen A, Tsybovsky Y, Park YJ, Bick MJ, Sankaran B, Gillespie RA, Brouwer PJ, Zwart PH, Veesler D, Kanekiyo M, Graham BS, Sanders RW, Moore JP, Klasse PJ, Ward AB, King NP, Baker D. "Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens." eLife 2020 08 04 ;9link

    4. Hambarde S, Tsai CL, Pandita RK, Bacolla A, Maitra A, Charaka V, Hunt CR, Kumar R, Limbo O, Le Meur R, Chazin WJ, Tsutakawa SE, Russell P, Schlacher K, Pandita TK, Tainer JA. "EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart." Molecular cell 2021 07 15 ;81(14):2989-3006.e9 link

    5. Leite WC, Weiss KL, Phillips G, Zhang Q, Qian S, Tsutakawa SE, Coates L, O'Neill H. "Conformational Dynamics in the Interaction of SARS-CoV-2 Papain-like Protease with Human Interferon-Stimulated Gene 15 Protein." The journal of physical chemistry letters 2021 Jun 17 ;12(23):5608-5615 link

    6. Paar M, Fengler VH, Rosenberg DJ, Krebs A, Stauber RE, Oettl K, Hammel M. "Albumin in patients with liver disease shows an altered conformation." Communications biology 2021 06 14 ;4(1):731 link

    7. Wilamowski M, Hammel M, Leite W, Zhang Q, Kim Y, Weiss KL, Jedrzejczak R, Rosenberg DJ, Fan Y, Wower J, Bierma JC, Sarker AH, Tsutakawa SE, Pingali SV, O'Neill HM, Joachimiak A, Hura GL. "Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication." Biophysical journal 2021 Jun 29 link

    8. Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM. "Discovery and characterization of bromodomain 2-specific inhibitors of BRDT." Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 02 ;118(9)link

    9. McConnell SA, McAllister RA, Amer BR, Mahoney BJ, Sue CK, Chang C, Ton-That H, Clubb RT. "Sortase-assembled pili in Corynebacterium diphtheriae are built using a latch mechanism." Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 23 ;118(12)link

    10. Wang X, Pereira JH, Tsutakawa S, Fang X, Adams PD, Mukhopadhyay A, Lee TS. "Efficient production of oxidized terpenoids via engineering fusion proteins of terpene synthase and cytochrome P450." Metabolic engineering 2021 03 ;64:41-51 link

    11. Walker RG, Kattamuri C, Goebel EJ, Zhang F, Hammel M, Tainer JA, Linhardt RJ, Thompson TB. "Heparin-mediated dimerization of follistatin." Experimental biology and medicine (Maywood, N.J.) 2021 Feb ;246(4):467-482 link

    12. Lapenta F, Aupič J, Vezzoli M, Strmšek Ž, Da Vela S, Svergun DI, Carazo JM, Melero R, Jerala R. "Self-assembly and regulation of protein cages from pre-organised coiled-coil modules." Nature communications 2021 02 11 ;12(1):939 link

    13. Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA. "Mechanism of efficient double-strand break repair by a long non-coding RNA." Nucleic acids research 2021 01 25 ;49(2):1199-1200 link

    14. Yu D, Kaur G, Blumenthal RM, Zhang X, Cheng X. "Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima." The Journal of biological chemistry 2021 Jan 08 :100270 link

    15. Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, De Yoreo JJ, Kollman JM, Ruohola-Baker H, Derivery E, Baker D. "Design of biologically active binary protein 2D materials." Nature 2021 01 ;589(7842):468-473 link

    16. Gunn KH, Gutgsell AR, Xu Y, Johnson CV, Liu J, Neher SB. "Comparison of angiopoietin-like protein 3 and 4 reveals structural and mechanistic similarities." Jan 2021, The Journal of biological chemistry ;296:100312 link

    17. Hsia Y, Mout R, Sheffler W, Edman NI, Vulovic I, Park YJ, Redler RL, Bick MJ, Bera AK, Courbet A, Kang A, Brunette TJ, Nattermann U, Tsai E, Saleem A, Chow CM, Ekiert D, Bhabha G, Veesler D, Baker D. "Design of multi-scale protein complexes by hierarchical building block fusion." Nature communications 2021 04 16 ;12(1):2294 link

    18. Hodge CD, Rosenberg DJ, Grob P, Wilamowski M, Joachimiak A, Hura GL, Hammel M. "Rigid monoclonal antibodies improve detection of SARS-CoV-2 nucleocapsid protein." mAbs ;13(1):1905978 link

    19. Hammel M, Rashid I, Sverzhinsky A, Pourfarjam Y, Tsai MS, Ellenberger T, Pascal JM, Kim IK, Tainer JA, Tomkinson AE. "An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex." Nucleic acids research 2021 01 11 ;49(1):306-321 link


    1. Uhlemann EE, Yu CH, Patry J, Dolgova N, Lutsenko S, Muyldermans S, Dmitriev OY. "Nanobodies against the metal binding domains of ATP7B as tools to study copper transport in the cell." Metallomics : integrated biometal science 2020 12 23 ;12(12):1941-1950 link

    2. Walker RG, Kattamuri C, Goebel EJ, Zhang F, Hammel M, Tainer JA, Linhardt RJ, Thompson TB. "Heparin-mediated dimerization of follistatin." Experimental biology and medicine (Maywood, N.J.) 2020 Nov 16 :1535370220966296 link

    3. Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA. "Mechanism of efficient double-strand break repair by a long non-coding RNA." Nucleic acids research 2020 11 04 ;48(19):10953-10972 link

    4. Lees-Miller JP, Cobban A, Katsonis P, Bacolla A, Tsutakawa SE, Hammel M, Meek K, Anderson DW, Lichtarge O, Tainer JA, Lees-Miller SP. "Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease." Progress in biophysics and molecular biology 2020 Oct 06 link

    5. Zeng Y, Ren R, Kaur G, Hardikar S, Ying Z, Babcock L, Gupta E, Zhang X, Chen T, Cheng X. "The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation." Genes & development 2020 Oct 01 link

    6. Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, Lynch EM, Boyken SE, Huang PS, Stewart L, DiMaio F, Kollman JM, Luisi BF, Matsuura T, Catterall WA, Baker D. "Computational design of transmembrane pores." Nature 2020 09 ;585(7823):129-134 link

    7. Wyatt JW, Korasick DA, Qureshi IA, Campbell AC, Gates KS, Tanner JJ. "Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1." Archives of biochemistry and biophysics 2020 Sep 30 ;691:108477 link

    8. Banda DM, Pereira JH, Liu AK, Orr DJ, Hammel M, He C, Parry MAJ, Carmo-Silva E, Adams PD, Banfield JF, Shih PM. "Novel bacterial clade reveals origin of form I Rubisco." Nature plants 2020 Sep ;6(9):1158-1166 link

    9. Pinals RL, Yang D, Rosenberg DJ, Chaudhary T, Crothers AR, Iavarone AT, Hammel M, Landry M. "Quantitative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments." Angewandte Chemie (International ed. in English) 2020 Sep 15 link

    10. Hammel M, Rosenberg DJ, Bierma J, Hura GL, Lees-Miller SP, Tainer JA. "Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM." Progress in biophysics and molecular biology 2020 Sep 20 link

    11. Dominguez-Martin MA, Hammel M, Gupta S, Lechno-Yossef S, Sutter M, Rosenberg DJ, Chen Y, Petzold CJ, Ralston CY, Polívka T, Kerfeld CA. "Structural analysis of a new carotenoid-binding protein: the C-terminal domain homolog of the OCP." Scientific reports 2020 Sep 23 ;10(1):15564 link

    12. Ueda G, Antanasijevic A, Fallas JA, Sheffler W, Copps J, Ellis D, Hutchinson GB, Moyer A, Yasmeen A, Tsybovsky Y, Park YJ, Bick MJ, Sankaran B, Gillespie RA, Brouwer PJ, Zwart PH, Veesler D, Kanekiyo M, Graham BS, Sanders RW, Moore JP, Klasse PJ, Ward AB, King NP, Baker D. "Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens." Elife 2020 08 04 ;9link

    13. Eckelmann BJ, Bacolla A, Wang H, Ye Z, Guerrero EN, Jiang W, El-Zein R, Hegde ML, Tomkinson AE, Tainer JA, Mitra S. "XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells." NAR Cancer 2020 Sep ;2(3):zcaa013 link

    14. Sloutsky R, Dziedzic N, Dunn MJ, Bates RM, Torres-Ocampo AP, Boopathy S, Page B, Weeks JG, Chao LH, Stratton MM. "Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation." Science signaling 2020 07 21 ;13(641)link

    15. Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, DiMaio F, Im YJ, Yoshimori T, Hurley JH. "Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex." Proc. Natl. Acad. Sci. U.S.A. 2020 Jul 21 ;117(29):17003-17010 link

    16. Jiao L, Shubbar M, Yang X, Zhang Q, Chen S, Wu Q, Chen Z, Rizo J, Liu X. "A partially disordered region connects gene repression and activation functions of EZH2." Proc. Natl. Acad. Sci. U.S.A. 2020 Jul 06 link

    17. Huang L, Wright M, Yang S, Blachowicz L, Makowski L, Roux B. "Glycine substitution in SH3-SH2 connector of Hck tyrosine kinase causes population shift from assembled to disassembled state." Biochim Biophys Acta Gen Subj 2020 Jul ;1864(7):129604 link

    18. Schellenberg MJ, Appel CD, Riccio AA, Butler LR, Krahn JM, Liebermann JA, Cortés-Ledesma F, Williams RS. "Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2." Nucleic acids research 2020 06 19 ;48(11):6310-6325 link

    19. Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X. "KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells." NAR cancer 2020 Jun ;2(2):zcaa007 link

    20. Marcum RD, Reyes AA, He Y. "Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex." Biology (Basel) 2020 Jun 30 ;9(7)link

    21. Crickard JB, Moevus CJ, Kwon Y, Sung P, Greene EC. "Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination." Cell 2020 Jun 11 ;181(6):1380-1394.e18 link

    22. Yan NL, Santos-Martins D, Rennella E, Sanchez BB, Chen JS, Kay LE, Wilson IA, Morgan GJ, Forli S, Kelly JW. "Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins." Bioorg. Med. Chem. Lett. 2020 Aug 15 ;30(16):127356 link

    23. Remesh SG, Verma SC, Chen JH, Ekman AA, Larabell CA, Adhya S, Hammel M. "Nucleoid remodeling during environmental adaptation is regulated by HU-dependent DNA bundling." Nat Commun 2020 Jun 09 ;11(1):2905 link

    24. Schellenberg MJ, Appel CD, Riccio AA, Butler LR, Krahn JM, Liebermann JA, Cortés-Ledesma F, Williams RS. "Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2." Nucleic Acids Res. 2020 Jun 19 ;48(11):6310-6325 link

    25. DuPrez K, He F, Chen Z, Hilario E, Fan L. "Structural basis of the XPB-Bax1 complex as a dynamic helicase-nuclease machinery for DNA repair." Nucleic Acids Res. 2020 Jun 19 ;48(11):6326-6339 link

    26. Tsutakawa SE, Sarker AH, Ng C, Arvai AS, Shin DS, Shih B, Jiang S, Thwin AC, Tsai MS, Willcox A, Her MZ, Trego KS, Raetz AG, Rosenberg D, Bacolla A, Hammel M, Griffith JD, Cooper PK, Tainer JA. "Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations." Proc. Natl. Acad. Sci. U.S.A. 2020 Jun 23 ;117(25):14127-14138 link

    27. Oh DY, Matsumoto Y, Kitajiri SI, Kim NKD, Kim MY, Kim AR, Lee M, Lee C, Tomkinson AE, Katsuno T, Kim SY, Shin HW, Han JH, Lee S, Park WY, Choi BY. "POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features." Hum. Mutat. 2020 May ;41(5):913-920 link

    28. Seacrist CD, Kuenze G, Hoffmann RM, Moeller BE, Burke JE, Meiler J, Blind RD. "Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function." Structure 2020 May 19 link

    29. Laciak AR, Korasick DA, Gates KS, Tanner JJ. "Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy." J. Inherit. Metab. Dis. 2020 May ;43(3):635-644 link

    30. Gorelik A, Illes K, Nagar B. "Crystal Structure of the Mannose-6-Phosphate Uncovering Enzyme." Structure (London, England : 1993) 2020 04 07 ;28(4):426-436.e3 link

    31. Chandrasekharan NP, Ravenburg CM, Roy IR, Monroe JD, Berndsen CE. "Solution structure and assembly of β-amylase 2 from Arabidopsis thaliana." Acta crystallographica. Section D, Structural biology 2020 Apr 01 ;76(Pt 4):357-365 link

    32. Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE. "Structural basis for allosteric PARP-1 retention on DNA breaks." Science 2020 04 03 ;368(6486)link

    33. Brunette TJ, Bick MJ, Hansen JM, Chow CM, Kollman JM, Baker D. "Modular repeat protein sculpting using rigid helical junctions." Proc. Natl. Acad. Sci. U.S.A. 2020 Apr 03 link

    34. Chen Z, Kibler RD, Hunt A, Busch F, Pearl J, Jia M, VanAernum ZL, Wicky BIM, Dods G, Liao H, Wilken MS, Ciarlo C, Green S, El-Samad H, Stamatoyannopoulos J, Wysocki VH, Jewett MC, Boyken SE, Baker D. "De novo design of protein logic gates." Science 2020 04 03 ;368(6486):78-84 link

    35. Chandrasekharan NP, Ravenburg CM, Roy IR, Monroe JD, Berndsen CE. "Solution structure and assembly of β-amylase 2 from Arabidopsis thaliana." Acta crystallographica. Section D, Structural biology 2020 Apr 01 ;76(Pt 4):357-365 link

    36. Wei KY, Moschidi D, Bick MJ, Nerli S, McShan AC, Carter LP, Huang PS, Fletcher DA, Sgourakis NG, Boyken SE, Baker D. "Computational design of closely related proteins that adopt two well-defined but structurally divergent folds." Proc. Natl. Acad. Sci. U.S.A. 2020 03 31 ;117(13):7208-7215 link

    37. Topolska-Woś AM, Sugitani N, Cordoba JJ, Le Meur KV, Le Meur RA, Kim HS, Yeo JE, Rosenberg D, Hammel M, Schärer OD, Chazin WJ. "A key interaction with RPA orients XPA in NER complexes." Nucleic Acids Res. 2020 02 28 ;48(4):2173-2188 link

    38. Smith IW, d'Aquino AE, Coyle CW, Fedanov A, Parker ET, Denning G, Spencer HT, Lollar P, Doering CB, Spiegel PC. "The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain." Journal of thrombosis and haemostasis : JTH 2020 01 ;18(1):57-69 link

    39. Russelburg LP, O'Shea Murray VL, Demir M, Knutsen KR, Sehgal SL, Cao S, David SS, Horvath MP. "Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY." ACS chemical biology 2020 01 17 ;15(1):93-102 link

    40. Gao ZZ, Wang ZK, Wei L, Yin G, Tian J, Liu CZ, Wang H, Zhang DW, Zhang YB, Li X, Liu Y, Li ZT. "Water-Soluble 3D Covalent Organic Framework that Displays an Enhanced Enrichment Effect of Photosensitizers and Catalysts for the Reduction of Protons to H2." ACS Appl Mater Interfaces 2020 Jan 08 ;12(1):1404-1411 link

    41. Herrmann J, Li PN, Jabbarpour F, Chan ACK, Rajkovic I, Matsui T, Shapiro L, Smit J, Weiss TM, Murphy MEP, Wakatsuki S. "A bacterial surface layer protein exploits multistep crystallization for rapid self-assembly." Proc. Natl. Acad. Sci. U.S.A. 2020 01 07 ;117(1):388-394 link

    42. Tsai CL, Tripp P, Sivabalasarma S, Zhang C, Rodriguez-Franco M, Wipfler RL, Chaudhury P, Banerjee A, Beeby M, Whitaker RJ, Tainer JA, Albers SV. "The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility." Nat Microbiol 2020 01 ;5(1):216-225 link

    43. Weinhardt V, Chen JH, Ekman AA, Guo J, Remesh SG, Hammel M, McDermott G, Chao W, Oh S, Le Gros MA, Larabell CA. "Switchable resolution in soft x-ray tomography of single cells." PLoS ONE 2020 ;15(1):e0227601 link


    1. Hura GL, Hodge CD, Rosenberg D, Guzenko D, Duarte JM, Monastyrskyy B, Grudinin S, Kryshtafovych A, Tainer JA, Fidelis K, Tsutakawa SE. "Small angle X-ray scattering-assisted protein structure prediction in CASP13 and emergence of solution structure differences." Proteins 2019 12 ;87(12):1298-1314 link

    2. Reimer JM, Eivaskhani M, Harb I, Guarné A, Weigt M, Schmeing TM. "Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility." Science 2019 11 08 ;366(6466)link

    3. Foster B, Rosenberg D, Salvo H, Stephens KL, Bintz BJ, Hammel M, Ellenberger T, Gainey MD, Wallen J. "Combined Solution and Crystal Methods Reveal the Electrostatic Tethers That Provide a Flexible Platform for Replication Activities in the Bacteriophage T7 Replisome." Biochemistry 2019 Oct 29 link

    4. Xuan S, Jiang X, Spencer RK, Li NK, Prendergast D, Balsara NP, Zuckermann RN. "Atomic-level engineering and imaging of polypeptoid crystal lattices." Proc. Natl. Acad. Sci. U.S.A. 2019 Oct 21 link

    5. Urusova DV, Kinsella RL, Salinas ND, Haurat MF, Feldman MF, Tolia NH. "The structure of Acinetobacter-secreted protease CpaA complexed with its chaperone CpaB reveals a novel mode of a T2SS chaperone-substrate interaction." J. Biol. Chem. 2019 Sep 06 ;294(36):13344-13354 link

    6. Sathyanarayanan N, Cannone G, Gakhar L, Katagihallimath N, Sowdhamini R, Ramaswamy S, Vinothkumar KR. "Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway." Nat Commun 2019 Sep 11 ;10(1):4127 link

    7. Horst BG, Yokom AL, Rosenberg DJ, Morris KL, Hammel M, Hurley JH, Marletta MA. "Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy." Elife 2019 Sep 30 ;8link

    8. Koirala D, Shao Y, Koldobskaya Y, Fuller JR, Watkins AM, Shelke SA, Pilipenko EV, Das R, Rice PA, Piccirilli JA. "A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites." Nat Commun 2019 Aug 09 ;10(1):3629 link

    9. Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. "Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a." Elife 2019 Aug 09 ;8link

    10. Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFB, Glover JNM. "Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis." Structure 2019 Aug 06 link

    11. Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. "Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP." Proc. Natl. Acad. Sci. U.S.A. 2019 Aug 13 ;116(33):16347-16356 link

    12. Miller TW, Amason JD, Garcin ED, Lamy L, Dranchak PK, Macarthur R, Braisted J, Rubin JS, Burgess TL, Farrell CL, Roberts DD, Inglese J. "Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors." PLoS ONE 2019 ;14(7):e0218897 link

    13. Langan RA, Boyken SE, Ng AH, Samson JA, Dods G, Westbrook AM, Nguyen TH, Lajoie MJ, Chen Z, Berger S, Mulligan VK, Dueber JE, Novak WRP, El-Samad H, Baker D. "De novo design of bioactive protein switches." Nature 2019 Aug ;572(7768):205-210 link

    14. Pyles H, Zhang S, De Yoreo JJ, Baker D. "Controlling protein assembly on inorganic crystals through designed protein interfaces." Nature 2019 07 ;571(7764):251-256 link

    15. Stachowski T, Grant TD, Snell EH. "Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses." J Synchrotron Radiat 2019 Jul 01 ;26(Pt 4):967-979 link

    16. Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X. "Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling." Structure 2019 Aug 06 ;27(8):1296-1307.e5 link

    17. Boyken SE, Benhaim MA, Busch F, Jia M, Bick MJ, Choi H, Klima JC, Chen Z, Walkey C, Mileant A, Sahasrabuddhe A, Wei KY, Hodge EA, Byron S, Quijano-Rubio A, Sankaran B, King NP, Lippincott-Schwartz J, Wysocki VH, Lee KK, Baker D. "De novo design of tunable, pH-driven conformational changes." Science 2019 05 17 ;364(6441):658-664 link

    18. D'Arcy BM, Blount J, Prakash A. "Biochemical and structural characterization of two variants of uncertain significance in the PMS2 gene." Hum. Mutat. 2019 Apr ;40(4):458-471 link

    19. Zhu J, Muia J, Gupta G, Westfield LA, Vanhoorelbeke K, Tolia NH, Sadler JE. "Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering." Blood 2019 Apr 25 ;133(17):1909-1918 link

    20. Y Meng, L Xu-Bo, G Zhong-Zheng, W Yi-Peng, H Jun-Li, W Hui, Z Dan-Wei, L Yi, L Zhan-Ting "A pore-expanded supramolecular organic framework and its enrichment of photosensitizers and catalysts for visible-light-induced hydrogen production."Org. Chem. Front. 2019 Apr 16; 6(10):1698-1704

    21. Shahul Hameed UF, Liao C, Radhakrishnan AK, Huser F, Aljedani SS, Zhao X, Momin AA, Melo FA, Guo X, Brooks C, Li Y, Cui X, Gao X, Ladbury JE, Jaremko Ł, Jaremko M, Li J, Arold ST. "H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing." Nucleic Acids Res. 2019 03 18 ;47(5):2666-2680 link

    22. Klass SH, Smith MJ, Fiala TA, Lee JP, Omole AO, Han BG, Downing KH, Kumar S, Francis MB. "Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain." J. Am. Chem. Soc. 2019 Mar 13 ;141(10):4291-4299 link

    23. Chanthamontri CK, Jordan DS, Wang W, Wu C, Lin Y, Brett TJ, Gross ML, Leung DW. "The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer." Biochemistry 2019 Feb 12 ;58(6):657-664 link

    24. Qualley DF, Cooper SE, Ross JL, Olson ED, Cantara WA, Musier-Forsyth K. "Solution Conformation of Bovine Leukemia Virus Gag Suggests an Elongated Structure." J. Mol. Biol. 2019 Mar 15 ;431(6):1203-1216 link

    25. Korasick DA, Končitíková R, Kopečná M, Hájková E, Vigouroux A, Moréra S, Becker DF, Šebela M, Tanner JJ, Kopečný D. "Structural and Biochemical Characterization of Aldehyde Dehydrogenase 12, the Last Enzyme of Proline Catabolism in Plants." J Mol Biol. 2019 Feb 1;431(3):576-592. link

    26. Chen Z, Boyken SE, Jia M, Busch F, Flores-Solis D, Bick MJ, Lu P, VanAernum ZL, Sahasrabuddhe A, Langan RA, Bermeo S, Brunette TJ, Mulligan VK, Carter LP, DiMaio F, Sgourakis NG, Wysocki VH, Baker D. "Programmable design of orthogonal protein heterodimers." Nature 2019 01 ;565(7737):106-111 link

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