Highlights & Publications from 2018

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  1. De-la-Torre P, Choudhary D, Araya-Secchi R, Narui Y, Sotomayor M. “A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15.” Biophys. J. 2018 Dec 18 ;115(12):2368-2385 link
  2. Tang HYH, Shin DS, Hura GL, Yang Y, Hu X, Lightstone FC, McGee MD, Padgett HS, Yannone SM, Tainer JA. “Structural Control of Nonnative Ligand Binding in Engineered Mutants of Phosphoenolpyruvate Carboxykinase.” Biochemistry 2018 Dec 04 ;57(48):6688-6700 link
  3. Schneidman-Duhovny D, Hammel M. “Modeling Structure and Dynamics of Protein Complexes with SAXS Profiles.” Methods Mol. Biol. 2018 ;1764:449-473 link
  4. Chen Z, Boyken SE, Jia M, Busch F, Flores-Solis D, Bick MJ, Lu P, VanAernum ZL, Sahasrabuddhe A, Langan RA, Bermeo S, Brunette TJ, Mulligan VK, Carter LP, DiMaio F, Sgourakis NG, Wysocki VH, Baker D. “Programmable design of orthogonal protein heterodimers.” Nature 2019 01 ;565(7737):106-111 link
  5. Pham VV, Salguero C, Khan SN, Meagher JL, Brown WC, Humbert N, de Rocquigny H, Smith JL, D’Souza VM. “HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry.” Nat Commun 2018 10 15 ;9(1):4266 link
  6. Caviness P, Bauer R, Tanaka K, Janowska K, Roeser JR, Harter D, Sanders J, Ruth C, Matsushita O, Sakon J. “Ca2+ -induced orientation of tandem collagen binding domains from clostridial collagenase ColG permits two opposing functions of collagen fibril formation and retardation.” FEBS J. 2018 Sep ;285(17):3254-3269 link
  7. Li Q, Gakhar L, Ashley Spies M. “Determinants of human glucokinase activation and implications for small molecule allosteric control.” Biochim Biophys Acta Gen Subj 2018 09 ;1862(9):1902-1912 link
  8. Zhang S, Zhou P, Wang P, Li Y, Jiang L, Jia W, Wang H, Fan A, Wang D, Shi X, Fang X, Hammel M, Wang S, Wang X, Zhang L. “Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein.” Cell Rep 2018 Jul 10 ;24(2):441-452 link
  9. Remesh SG, Armstrong AA, Mahan AD, Luo J, Hammel M. “Conformational Plasticity of the Immunoglobulin Fc Domain in Solution.” Structure 2018 Jul 03 ;26(7):1007-1014.e2 link
  10. Ramadan AM, Daguindau E, Rech JC, Chinnaswamy K, Zhang J, Hura GL, Griesenauer B, Bolten Z, Robida A, Larsen M, Stuckey JA, Yang CY, Paczesny S. “From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.” JCI Insight 2018 Jul 25 ;3(14)link
  11. Zettl T, Das R, Harbury PAB, Herschlag D, Lipfert J, Mathew RS, Shi X. “Recording and Analyzing Nucleic Acid Distance Distributions with X-Ray Scattering Interferometry (XSI).” Curr Protoc Nucleic Acid Chem 2018 06 ;73(1):e54 link
  12. Johnson CN, Potet F, Thompson MK, Kroncke BM, Glazer AM, Voehler MW, Knollmann BC, George AL, Chazin WJ. “A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.” Structure 2018 May 01 ;26(5):683-694.e3 link
  13. Cho C, Chande AT, Gakhar L, Hunt J, Ketterer MR, Apicella MA. “Characterization of a nontypeable Haemophilus influenzae thermonuclease.” PLoS ONE 2018 ;13(5):e0197010 link
  14. Ogorzalek TL, Hura GL, Belsom A, Burnett KH, Kryshtafovych A, Tainer JA, Rappsilber J, Tsutakawa SE, Fidelis K. “Small angle X-ray scattering and cross-linking for data assisted protein structure prediction in CASP 12 with prospects for improved accuracy.” Proteins 2018 Mar ;86 Suppl 1:202-214 link
  15. Banerjee R, Yoder JB, Yue DT, Amzel LM, Tomaselli GF, Gabelli SB, Ben-Johny M. “Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels.” Proc. Natl. Acad. Sci. U.S.A. 2018 03 27 ;115(13):E3026-E3035 link
  16. Guo HF, Tsai CL, Terajima M, Tan X, Banerjee P, Miller MD, Liu X, Yu J, Byemerwa J, Alvarado S, Kaoud TS, Dalby KN, Bota-Rabassedas N, Chen Y, Yamauchi M, Tainer JA, Phillips GN, Kurie JM. “Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.” Nat Commun 2018 02 06 ;9(1):512 link
  17. Chang A, Abderemane-Ali F, Hura GL, Rossen ND, Gate RE, Minor DL. “A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function.” Neuron 2018 Feb 21 ;97(4):836-852.e6 link
  18. Moiani D, Ronato DA, Brosey CA, Arvai AS, Syed A, Masson JY, Petricci E, Tainer JA. “Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities.” Meth. Enzymol. 2018 ;601:205-241 link
  19. Lo YH, Pillon MC, Stanley RE. “Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae.” J Vis Exp 2018 01 10 (131) link
  20. Walker RG, McCoy JC, Czepnik M, Mills MJ, Hagg A, Walton KL, Cotton TR, Hyvönen M, Lee RT, Gregorevic P, Harrison CA, Thompson TB. “Molecular characterization of latent GDF8 reveals mechanisms of activation.” Proceedings of the National Academy of Sciences. National Academy of Sciences; 2018 Jan 30;115(5):E866–75 link