Highlights & Publications from 2020

  1. Uhlemann EE, Yu CH, Patry J, Dolgova N, Lutsenko S, Muyldermans S, Dmitriev OY. “Nanobodies against the metal binding domains of ATP7B as tools to study copper transport in the cell.” Metallomics : integrated biometal science 2020 12 23 ;12(12):1941-1950 link
  2. Walker RG, Kattamuri C, Goebel EJ, Zhang F, Hammel M, Tainer JA, Linhardt RJ, Thompson TB. “Heparin-mediated dimerization of follistatin.” Experimental biology and medicine (Maywood, N.J.) 2020 Nov 16 :1535370220966296 link
  3. Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA. “Mechanism of efficient double-strand break repair by a long non-coding RNA.” Nucleic acids research 2020 11 04 ;48(19):10953-10972 link
  4. Stachowski TR, Snell ME, Snell EH. “SAXS studies of X-ray induced disulfide bond damage: Engineering high-resolution insight from a low-resolution technique.” PloS one 2020 ;15(11):e0239702 link
  5. Lees-Miller JP, Cobban A, Katsonis P, Bacolla A, Tsutakawa SE, Hammel M, Meek K, Anderson DW, Lichtarge O, Tainer JA, Lees-Miller SP. “Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease.” Progress in biophysics and molecular biology 2020 Oct 06 link
  6. Zeng Y, Ren R, Kaur G, Hardikar S, Ying Z, Babcock L, Gupta E, Zhang X, Chen T, Cheng X. “The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation.” Genes & development 2020 Oct 01 link
  7. Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, Lynch EM, Boyken SE, Huang PS, Stewart L, DiMaio F, Kollman JM, Luisi BF, Matsuura T, Catterall WA, Baker D. “Computational design of transmembrane pores.” Nature 2020 09 ;585(7823):129-134 link
  8. Wyatt JW, Korasick DA, Qureshi IA, Campbell AC, Gates KS, Tanner JJ. “Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1.” Archives of biochemistry and biophysics 2020 Sep 30 ;691:108477 link
  9. Banda DM, Pereira JH, Liu AK, Orr DJ, Hammel M, He C, Parry MAJ, Carmo-Silva E, Adams PD, Banfield JF, Shih PM. “Novel bacterial clade reveals origin of form I Rubisco.” Nature plants 2020 Sep ;6(9):1158-1166 link
  10. Pinals RL, Yang D, Rosenberg DJ, Chaudhary T, Crothers AR, Iavarone AT, Hammel M, Landry M. “Quantitative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments.” Angewandte Chemie (International ed. in English) 2020 Sep 15 link
  11. Hammel M, Rosenberg DJ, Bierma J, Hura GL, Lees-Miller SP, Tainer JA. “Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM.” Progress in biophysics and molecular biology 2020 Sep 20 link
  12. Dominguez-Martin MA, Hammel M, Gupta S, Lechno-Yossef S, Sutter M, Rosenberg DJ, Chen Y, Petzold CJ, Ralston CY, Polívka T, Kerfeld CA. “Structural analysis of a new carotenoid-binding protein: the C-terminal domain homolog of the OCP.” Scientific reports 2020 Sep 23 ;10(1):15564 link
  13. Ueda G, Antanasijevic A, Fallas JA, Sheffler W, Copps J, Ellis D, Hutchinson GB, Moyer A, Yasmeen A, Tsybovsky Y, Park YJ, Bick MJ, Sankaran B, Gillespie RA, Brouwer PJ, Zwart PH, Veesler D, Kanekiyo M, Graham BS, Sanders RW, Moore JP, Klasse PJ, Ward AB, King NP, Baker D. “Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens.” Elife 2020 08 04 ;9link
  14. Eckelmann BJ, Bacolla A, Wang H, Ye Z, Guerrero EN, Jiang W, El-Zein R, Hegde ML, Tomkinson AE, Tainer JA, Mitra S. “XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells.” NAR Cancer 2020 Sep ;2(3):zcaa013 link
  15. Sloutsky R, Dziedzic N, Dunn MJ, Bates RM, Torres-Ocampo AP, Boopathy S, Page B, Weeks JG, Chao LH, Stratton MM. “Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation.” Science signaling 2020 07 21 ;13(641)link
  16. Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, DiMaio F, Im YJ, Yoshimori T, Hurley JH. “Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.” Proc. Natl. Acad. Sci. U.S.A. 2020 Jul 21 ;117(29):17003-17010 link
  17. Jiao L, Shubbar M, Yang X, Zhang Q, Chen S, Wu Q, Chen Z, Rizo J, Liu X. “A partially disordered region connects gene repression and activation functions of EZH2.” Proc. Natl. Acad. Sci. U.S.A. 2020 Jul 06 link
  18. Huang L, Wright M, Yang S, Blachowicz L, Makowski L, Roux B. “Glycine substitution in SH3-SH2 connector of Hck tyrosine kinase causes population shift from assembled to disassembled state.” Biochim Biophys Acta Gen Subj 2020 Jul ;1864(7):129604 link
  19. Schellenberg MJ, Appel CD, Riccio AA, Butler LR, Krahn JM, Liebermann JA, Cortés-Ledesma F, Williams RS. “Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.” Nucleic acids research 2020 06 19 ;48(11):6310-6325 link
  20. Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X. “KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells.” NAR cancer 2020 Jun ;2(2):zcaa007 link
  21. Marcum RD, Reyes AA, He Y. “Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex.” Biology (Basel) 2020 Jun 30 ;9(7)link
  22. Crickard JB, Moevus CJ, Kwon Y, Sung P, Greene EC. “Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination.” Cell 2020 Jun 11 ;181(6):1380-1394.e18 link
  23. Yan NL, Santos-Martins D, Rennella E, Sanchez BB, Chen JS, Kay LE, Wilson IA, Morgan GJ, Forli S, Kelly JW. “Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins.” Bioorg. Med. Chem. Lett. 2020 Aug 15 ;30(16):127356 link
  24. Remes