Scott Classen: July 2013 Archives
Several new crystal structures of the 70S ribosome in complex with EFG and non-hydrolyzable GTP analogs have revealed how the ribosome directionally translocates mRNA and the tRNAs through the A, P, and E sites and how specific features of EFG and ribosomal RNA act as pawls to enforce this ratcheting mechanism. The new structures were solved in the Cate, Noller, and Ramakrishnan labs and were published in the June 28 edition of Science. Many of the new structures were made possible by data collected at the SIBYLS beamline.
If you want the boiled down version of these new results then read this succinct comment by Marina Rodnina.
A figure liberally lifted from her comment.
We spent many long nights at the Advanced Light Source, running on coffee, donuts and barbecued ribs from the legendary Everett & Jones BBQ in West Berkeley.
A very interesting historical reflection by Harry Noller entitled “By Ribosome Possessed” has just been published in JBC. It is his personal account of growing up in the East Bay; his educational, musical, and scientific influences and how these gradually but inexorably led to an exciting and fruitful career studying “one of the deepest and most central mechanisms in all of biology”. The article is filled with funny and amazing anecdotes and gives a very human face to science, and to Harry’s impressively focused and singular pursuit of one of life’s most important molecules. A great read!