SIBYLS makes cover of Antibody Therapeutics
Analyzing SAXS data collected at SIBYLS beamline 12.3.1, Michal Hammel determined the structural arrangement of the VH and VL domains in the COBRA™ (COnditional Bispecific Redirected Activation) T-cell engagers. The study showed that the structural arrangement of the domains in COBRA is different from the expected yet the stable fold is maintained. Findings provide insights for design of the novel protein therapeutics.