Time-Resolved SAXS Screen of Small-Molecule Drug Candidates

SIBYLS made the news for work on time-resolved, high-throughput, small-angle x-ray scattering (SAXS) at the Advanced Light Source (ALS) improving the screening of small-molecule drug candidates, and providing insight into how they stimulate structural transitions in protein targets.

Publication: C.A. Brosey, T.M. Link, R. Shen, D. Moiani, K. Burnett, G.L. Hura, D.E. Jones, and J.A. Tainer, “Chemical screening by time-resolved X-ray scattering to discover allosteric probes,” Nat. Chem. Biol. (2024), doi:10.1038/s41589-024-01609-1.

Read the article in ALS News here.