SIBYLS made the news for work on time-resolved, high-throughput, small-angle x-ray scattering (SAXS) at the Advanced Light Source (ALS) improving the screening of small-molecule drug candidates, and providing insight into how they stimulate structural transitions in protein targets. Publication: C.A. Brosey, T.M. Link, R. Shen, D. Moiani, K. Burnett, G.L. Hura, D.E. Jones, and J.A.…
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Learn how to get the most out of your SAXS data from experts in the field and tour the SIBYLS beamline at the Advanced Light Source. During the workshop our beamline scientists will update you on the latest advances in SAXS with particular focus on advances in synchrotron scattering techniques, modeling of dynamic and flexible…
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Scientists at SIBYLS used small angle x-ray scattering to understand a microbial protein involved in the bifurcation of high and low energy electrons in microbial metabolism. By analyzing the SAXS data, the SIBYLS team was able to find that NADH activates the protein’s mechanics, allowing it to act as the wheel and ropes of a…
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SIBYLS beamline scientist, Michal Hammel, partners with BioCAT beamline scientist, Jesse Hopkins to lead a workshop on small angle and neutron scattering at the ACA 74th Annual Meeting in Denver, CO (July 7 -12). The workshop will be held on Sunday, July 7 from 8:00 AM – 5:30 PM (MT). For details, see Workshop 2…
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Anaerobic SEC-MALS-SAXS at the SIBYLS beamline of the Advanced Light Source probes the conformational states behind electron bifurcation in the Thermotoga maritima EtfABCX, revealing insights on mechanisms at the thermodynamic limits of life. Shown are the bifurcation- and electron-conducting-like states experimentally observed for the first time in solution. View the article.
For X-ray scattering and other structures in the areas of DNA replication, repair, and cancer biology, this is your last opportunity to apply to join the 6th DNA Repair/Replication Structures and Cancer Conference (DRRSC) chaired by John Tainer and Xiaodong Zhang. The conference focuses on mechanisms and structures including dynamic states. This is a biannual conference in Cancun 14…
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Using small angle x-ray scattering data collected at the SIBYLS beamline and a computer-based approach, researchers designed porous protein crystals that were revealed to be stable, tunable, and atomically accurate. The work provides a powerful new platform for biological materials engineering and opens up wide applications in biotechnology and medicine. Read more here.
We are pleased to announce that SIBYLS scientists, Greg Hura and Susan Tsutakawa, have been officially appointed to high-level positions within the Biosciences Molecular Biophysics and Integrated Bioimaging (MBIB) Division. Greg Hura will assume the role of MBIB Science Deputy while Susan Tsutakawa will take on Head of Structual Biology within the MBIB division. Go…
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