Science Highlights

Nobel Prize in Chemistry awarded to longtime SIBYLS user David Baker

David Baker, one of SIBYLS longest and most committed users, was awarded the Nobel Prize for Chemistry for his work in protein design. SAXS data collected from around 3,000 samples sent by the Baker Lab to the SIBYLS beamline over many years contributed to key advancements in the Baker Lab’s breakthroughs in protein design. Since…
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2024 BioSAXS Workshop

With talks from four fantastic outside speakers, Dr. John Hackett from Florida International University, Dr. David Buckley from Dr. John Tanner’s lab at the University of Missouri, Dr. Alex Kehl from Dr. Patrick Shi’s lab at UC Davis, and Dr. Josh Arens from Dr. Robert Waymouth’s lab at Stanford University, covering their wide-ranging scientific research…
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Time-Resolved SAXS Screen of Small-Molecule Drug Candidates

SIBYLS made the news for work on time-resolved, high-throughput, small-angle x-ray scattering (SAXS) at the Advanced Light Source (ALS) improving the screening of small-molecule drug candidates, and providing insight into how they stimulate structural transitions in protein targets. Publication: C.A. Brosey, T.M. Link, R. Shen, D. Moiani, K. Burnett, G.L. Hura, D.E. Jones, and J.A.…
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Join us for our 15th Annual BioSAXS Workshop on August 14th

Learn how to get the most out of your SAXS data from experts in the field and tour the SIBYLS beamline at the Advanced Light Source. During the workshop our beamline scientists will update you on the latest advances in SAXS with particular focus on advances in synchrotron scattering techniques, modeling of dynamic and flexible…
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SIBYLS research in Bifurcation of Electrons is highlighted in ALS Science Briefs newsletter

Scientists at SIBYLS used small angle x-ray scattering to understand a microbial protein involved in the bifurcation of high and low energy electrons in microbial metabolism. By analyzing the SAXS data, the SIBYLS team was able to find that NADH activates the protein’s mechanics, allowing it to act as the wheel and ropes of a…
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Applications of Small Angle Scattering to Structural Biology

SIBYLS beamline scientist, Michal Hammel, partners with BioCAT beamline scientist, Jesse Hopkins to lead a workshop on small angle and neutron scattering at the ACA 74th Annual Meeting in Denver, CO (July 7 -12). The workshop will be held on Sunday, July 7 from 8:00 AM – 5:30 PM (MT). For details, see Workshop 2…
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SIBYLS makes cover of Biochemistry

Anaerobic SEC-MALS-SAXS at the SIBYLS beamline of the Advanced Light Source probes the conformational states behind electron bifurcation in the Thermotoga maritima EtfABCX, revealing insights on mechanisms at the thermodynamic limits of life. Shown are the bifurcation- and electron-conducting-like states experimentally observed for the first time in solution. View the article.

6th DNA Repair/Replication Structures and Cancer Conference 14 Feb 2024 – 18 Feb 2024 Cancun, Mexico

For X-ray scattering and other structures in the areas of DNA replication, repair, and cancer biology, this is your last opportunity to apply to join the 6th DNA Repair/Replication Structures and Cancer Conference (DRRSC) chaired by John Tainer and Xiaodong Zhang. The conference focuses on mechanisms and structures including dynamic states. This is a biannual conference in Cancun 14…
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