Umanga Rupakheti, Sara Scanlan and Ruhi Rahman from Christopher Berndsen’s lab at James Madison University spent 4 weeks with the SIBYLS at LBNL working on their own research and helping around the wet lab this summer 2025. The students enjoyed hands-on experience collecting both SEC and HT-SAXS data and were mentored by SIBYLS Postdocs and…
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Michal Hammel will be speaking on Small Angle X-ray Scattering at the SIBYLS beamline 12.3.1 during the ALS User Meeting on Tuesday, August 12, 2025. The talk will be part of the Light Sources 101 workshop which is geared toward students and postdocs new to synchrotron experiments. The workshop will be held at the Double…
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The use of deep-learning and statistical methods plays a significant role in the prediction of accurate structure and atomistics RNA models. In this paper, the authors describe new a deep-learning tool they developed called Scoper, which is capable of using experimental SAXS data from the SIBYLS beam line to determine the most likely 3-dimensional conformation of…
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Integrative Structural Biology conference: The 7th DNA Replication/Repair Structures & Cancer Conference (7th DRRSC) will bring together scientists to exchange cutting-edge structural findings and stimulate new ideas and approaches to address the critical challenges in mechanistic cancer research at the interface of DNA replication and repair. Recent breakthroughs in experimental structural methodologies (particularly cryo-electron microscopy,…
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In this Baker paper, published in Nature Communications in November 2024, the authors describe the design of pseudosymmetric protein hetero-oligomers. These proteins are versatile building blocks for creating functional materials and controlling biological processes. The Baker group utilized SEC-SAXS and SEC-MALS data collected at the SIBYLS beamline in the design of these proteins. Read the…
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David Baker, one of SIBYLS longest and most committed users, was awarded the Nobel Prize for Chemistry for his work in protein design. SAXS data collected from around 3,000 samples sent by the Baker Lab to the SIBYLS beamline over many years contributed to key advancements in the Baker Lab’s breakthroughs in protein design. Since…
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With talks from four fantastic outside speakers, Dr. John Hackett from Florida International University, Dr. David Buckley from Dr. John Tanner’s lab at the University of Missouri, Dr. Alex Kehl from Dr. Patrick Shi’s lab at UC Davis, and Dr. Josh Arens from Dr. Robert Waymouth’s lab at Stanford University, covering their wide-ranging scientific research…
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SIBYLS made the news for work on time-resolved, high-throughput, small-angle x-ray scattering (SAXS) at the Advanced Light Source (ALS) improving the screening of small-molecule drug candidates, and providing insight into how they stimulate structural transitions in protein targets. Publication: C.A. Brosey, T.M. Link, R. Shen, D. Moiani, K. Burnett, G.L. Hura, D.E. Jones, and J.A.…
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