The use of deep-learning and statistical methods plays a significant role in the prediction of accurate structure and atomistics RNA models. In this paper, the authors describe new a deep-learning tool they developed called Scoper, which is capable of using experimental SAXS data from the SIBYLS beam line to determine the most likely 3-dimensional conformation of…
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Integrative Structural Biology conference: The 7th DNA Replication/Repair Structures & Cancer Conference (7th DRRSC) will bring together scientists to exchange cutting-edge structural findings and stimulate new ideas and approaches to address the critical challenges in mechanistic cancer research at the interface of DNA replication and repair. Recent breakthroughs in experimental structural methodologies (particularly cryo-electron microscopy,…
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In this Baker paper, published in Nature Communications in November 2024, the authors describe the design of pseudosymmetric protein hetero-oligomers. These proteins are versatile building blocks for creating functional materials and controlling biological processes. The Baker group utilized SEC-SAXS and SEC-MALS data collected at the SIBYLS beamline in the design of these proteins. Read the…
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David Baker, one of SIBYLS longest and most committed users, was awarded the Nobel Prize for Chemistry for his work in protein design. SAXS data collected from around 3,000 samples sent by the Baker Lab to the SIBYLS beamline over many years contributed to key advancements in the Baker Lab’s breakthroughs in protein design. Since…
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With talks from four fantastic outside speakers, Dr. John Hackett from Florida International University, Dr. David Buckley from Dr. John Tanner’s lab at the University of Missouri, Dr. Alex Kehl from Dr. Patrick Shi’s lab at UC Davis, and Dr. Josh Arens from Dr. Robert Waymouth’s lab at Stanford University, covering their wide-ranging scientific research…
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SIBYLS made the news for work on time-resolved, high-throughput, small-angle x-ray scattering (SAXS) at the Advanced Light Source (ALS) improving the screening of small-molecule drug candidates, and providing insight into how they stimulate structural transitions in protein targets. Publication: C.A. Brosey, T.M. Link, R. Shen, D. Moiani, K. Burnett, G.L. Hura, D.E. Jones, and J.A.…
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Learn how to get the most out of your SAXS data from experts in the field and tour the SIBYLS beamline at the Advanced Light Source. During the workshop our beamline scientists will update you on the latest advances in SAXS with particular focus on advances in synchrotron scattering techniques, modeling of dynamic and flexible…
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SIBYLS beamline scientist, Michal Hammel, partners with BioCAT beamline scientist, Jesse Hopkins to lead a workshop on small angle and neutron scattering at the ACA 74th Annual Meeting in Denver, CO (July 7 -12). The workshop will be held on Sunday, July 7 from 8:00 AM – 5:30 PM (MT). For details, see Workshop 2…
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