In this Baker paper, published in Nature Communications in November 2024, the authors describe the design of pseudosymmetric protein hetero-oligomers. These proteins are versatile building blocks for creating functional materials and controlling biological processes. The Baker group utilized SEC-SAXS and SEC-MALS data collected at the SIBYLS beamline in the design of these proteins. Read the…
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David Baker, one of SIBYLS longest and most committed users, was awarded the Nobel Prize for Chemistry for his work in protein design. SAXS data collected from around 3,000 samples sent by the Baker Lab to the SIBYLS beamline over many years contributed to key advancements in the Baker Lab’s breakthroughs in protein design. Since…
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With talks from four fantastic outside speakers, Dr. John Hackett from Florida International University, Dr. David Buckley from Dr. John Tanner’s lab at the University of Missouri, Dr. Alex Kehl from Dr. Patrick Shi’s lab at UC Davis, and Dr. Josh Arens from Dr. Robert Waymouth’s lab at Stanford University, covering their wide-ranging scientific research…
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SIBYLS made the news for work on time-resolved, high-throughput, small-angle x-ray scattering (SAXS) at the Advanced Light Source (ALS) improving the screening of small-molecule drug candidates, and providing insight into how they stimulate structural transitions in protein targets. Publication: C.A. Brosey, T.M. Link, R. Shen, D. Moiani, K. Burnett, G.L. Hura, D.E. Jones, and J.A.…
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Learn how to get the most out of your SAXS data from experts in the field and tour the SIBYLS beamline at the Advanced Light Source. During the workshop our beamline scientists will update you on the latest advances in SAXS with particular focus on advances in synchrotron scattering techniques, modeling of dynamic and flexible…
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SIBYLS beamline scientist, Michal Hammel, partners with BioCAT beamline scientist, Jesse Hopkins to lead a workshop on small angle and neutron scattering at the ACA 74th Annual Meeting in Denver, CO (July 7 -12). The workshop will be held on Sunday, July 7 from 8:00 AM – 5:30 PM (MT). For details, see Workshop 2…
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Anaerobic SEC-MALS-SAXS at the SIBYLS beamline of the Advanced Light Source probes the conformational states behind electron bifurcation in the Thermotoga maritima EtfABCX, revealing insights on mechanisms at the thermodynamic limits of life. Shown are the bifurcation- and electron-conducting-like states experimentally observed for the first time in solution. View the article.
For X-ray scattering and other structures in the areas of DNA replication, repair, and cancer biology, this is your last opportunity to apply to join the 6th DNA Repair/Replication Structures and Cancer Conference (DRRSC) chaired by John Tainer and Xiaodong Zhang. The conference focuses on mechanisms and structures including dynamic states. This is a biannual conference in Cancun 14…
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