Analyzing SAXS data collected at SIBYLS beamline 12.3.1, Michal Hammel determined the structural arrangement of the VH and VL domains in the COBRA™ (COnditional Bispecific Redirected Activation) T-cell engagers. The study showed that the structural arrangement of the domains in COBRA is different from the expected yet the stable fold is maintained. Findings provide insights…
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SIBYLS is excited to announce we have a biochemist postdoc fellow opening. This is a great opportunity to work with experienced and innovative scientists in the field of structural biology. We are looking for someone who wants to develop and apply biology for multi-component biological macromolecules. You will be a part of a team that…
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John Tainer, founder and PI of the SIBYLS group, now at MD Anderson Cancer Center, will be one of three chairs at the 5th DNA Repair/Replication Structures and Cancer Conference. The conference will focus on structural and mechanistic insights into dynamic complexes acting in DNA repair and its interface with replication, transcription and other cancer-relevant…
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SIBYLS has recently installed a new Agilent 1290 Infinity II LC system to enhance our SEC-SAXS capabilities with a high reliability and robustness, improving analytical, instrument, and laboratory efficiency. Features include more chromatographic resolution, higher peak capacity for challenging separations, lower carryover for uncompromised data quality, unique detection capabilities, faster injection cycles with dual needle…
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Save the date! SIBYLS will be holding a SAXS workshop during the ALS User meeting from August 25-27, 2020. Details about the workshop coming soon. You can find general information about the User Meeting on the ALS website.
SIBYLS is pleased to announce SAXS Frameslice, a new Webapp for merging frame sliced SAXS data. The Webapp was designed by Dave Shin with the purpose of improving your SAXS calculations by averaging the intensities of different regions of your data from multiple images of the same sample. With this Webapp you can: –…
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Date: October 2 – 3, 2019 Location: Building 33 at Lawrence Berkeley National Laboratory, Berkeley, CA Building / ROOM : 33-306 This two-day workshop will cover frontiers in biological SAXS and will provide participants with software tutorial sessions for biological SAXS in addition to hands-on training in experimental techniques. The latest advances in SAXS studies…
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** Date: October 3 – 4, 2018 Location: Advanced Light Source at Lawrence Berkeley National Laboratory, Berkeley, CA Building 33 room 306 The two-day workshop, held during [ALS user meeting](https://als.lbl.gov/user-meeting/ “ALS user meeting”), will provide participants with software tutorial sessions for biological SAXS in addition to hands-on training in experimental techniques. The latest advances in…
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