The SIBYLS beamline Kohzu monochromator has often exhibited hysteresis when moving the theta 2 motor. This manifests itself in a decaying beam and suboptimal intensity. In order to fully understand the problem it helps to have a general understanding of the motors in the monochromator. The figure below illustrates the various motors and their relative…
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In the September 19, 2008 issue of Cell, we report striking conformational rearrangements in the crystal structure of NEDD8~Cul5ctd-Rbx1 and SAXS analysis of NEDD8~Cul1ctd-Rbx1 relative to their unmodified counterparts. These results point to conformational control of Cullin-RING ligase (CRL) activity, with ligation of NEDD8 shifting equilibria to disfavor inactive closed architectures, and favor dynamic, open forms that promote polyubiquitination. Cullin-RING ligases…
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Due to DOE budget cuts and planned upgrades to the ALS storage ring we will have no light until October 11th. Hopefully we will be scheduling beamtime for Oct/Nov/Dec within the next couple of weeks. If you are interested in obtaining General Users shifts please fill out an online application.
Yeah! Come collect data on our newly upgraded ADSC Q315r area detector. Here is the "proof"
The structure of Sulfolobus acidocaldarius XPD has recently been solved and the biochemical activites of various disease causing mutations measured. Results are reported in the May 30th issue of Cell. LBNL has also done a nice write up.
a resource for HTS of crystallization conditions.
It’s gone! We boxed up our Q315 yesterday and sent it back to ADSC for an upgrade to the Q315r model. Essentially this is an upgrade to the amplifiers that read out the CCDs and the other associated electronics for getting the raw images to the detector computers for processing. The fiber optic…
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As of Monday April 7th – The Director of the National Institutes of Health shall require that all investigators funded by the NIH submit or have submitted for them to the National Library of Medicine’s PubMed Central an electronic version of their final, peer-reviewed manuscripts upon acceptance for publication, to be made publicly available no…
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