Science Highlights

6 Week Autumn Shutdown

Due to DOE budget cuts and planned upgrades to the ALS storage ring we will have no light until October 11th. Hopefully we will be scheduling beamtime for Oct/Nov/Dec within the next couple of weeks. If you are interested in obtaining General Users shifts please fill out an online application.

PX detector is back and better than ever

Yeah! Come collect data on our newly upgraded ADSC Q315r area detector. Here is the "proof"

The Structures and Biochemical Activities of XPD Helicase Reveal Vital Insights into Cancer and Aging Diseases

The structure of Sulfolobus acidocaldarius XPD has recently been solved and the biochemical activites of various disease causing mutations measured. Results are reported in the May 30th issue of Cell. LBNL has also done a nice write up.

High Throughput Crystal Screening at HWI

a resource for HTS of crystallization conditions.

Our detector is gone!

It’s gone! We boxed up our Q315 yesterday and sent it back to ADSC for an upgrade to the Q315r model.     Essentially this is an upgrade to the amplifiers that read out the CCDs and the other associated electronics for getting the raw images to the detector computers for processing. The fiber optic…
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NIH now requires open-access to manuscripts

As of Monday April 7th – The Director of the National Institutes of Health shall require that all investigators funded by the NIH submit or have submitted for them to the National Library of Medicine’s PubMed Central an electronic version of their final, peer-reviewed manuscripts upon acceptance for publication, to be made publicly available no…
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Crystals webapp Installed

The [crystals](http://bl1231.als.lbl.gov/crystals) server (an Apache Tomcat webapp) has been installed. The crystals webapp will allow you to upload an excel spreadsheet, containing a list of samples, to the SIBYLS beamline for use with DOMO. The spreadsheet will be automatically converted to an XML file and will become available to you via Blu-Ice once you start…
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Yeast Topoisomerase II bound to DNA

As recently [reported](http://www-als.lbl.gov/als/science/sci_archive/160topoII.html) in the ALSNews: > “The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of…
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