A group of 17 scientists from Genentech/Roche visited SIBYLS in March 2023. The group was headed by Dr. Chun-wan Yen (second from left, front row), a Senior Principal Scientist with Genentech based in San Fransisco. They were given a tour of the ALS experimental ring, including a extensive tour of the SIBYLS SAXS beamline 12.3.1.…
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The SIBYLS beamline was used to characterize proteins using reinforcement learning, an algorithm developed by frequent BL 12.3.1 users from David Baker’s lab at the University of Washington. Read the article here.
The presence of a carbohydrate-rich cell wall is a ubiquitous feature of all plants. While we are beginning to understand the composition and diversity of the polysaccharide components in these walls, little is known about the enzymes involved in their synthesis. By combing macromolecular X-ray crystallography together with solution X-ray scattering data collecting at beamline…
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Angela Kayll from James Madison University spent the summer of 2022 at SIBYLS working with our SAXS scientists and collecting SAXS data on Matlodextrin chains. Angela (Angie), was given a Biochemistry and Molecular Biology poster presentation award for this work at the 2022 Annual Biomedical Research Conference for Minority Students in Anaheim, CA. Her poster…
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Researchers from Genentech in collaboration with SIBYLS beamline scientist, Michal Hammel, used Small Angle X-Ray scattering to learn how an assembly of three proteins works together to transmit signals for cell division. The work reveals new targets for the development of drugs to fight certain types of cancer, including lung, colorectal, and pancreatic.
SIBYLS beamline scientists Daniel Rosenberg and Michal Hammel collaborated with the Shih Lab at UC Berkeley to study patterns of oligomerization in rubisco, nature’s most abundant carbon-fixing enzyme. By using SEC-SAXS-MALS, they were able to conduct a diversity-driven structural study across extant and ancestral form II rubisco and retrace the evolutionary trajectory taken during the…
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Join us for this 2-day SAXS workshop to be held via zoom during the 2022 ALS User Meeting. Registration is FREE. You will need to register for the ALS User Meeting and select the 13th Annual SIBYLS BioSAXS Workhop/tutorial. In addition, please email Kathryn at kburnett@lbl.gov and let her know you plan to attend (or…
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Our very own James Holton has organized what looks to be a fantastic Gordon Research Conference. Diffraction Methods in Structural Biology will be held in Lewiston Maine on the campus of Bates College, July 24 – 29, 2022. Come join us if you are able. Structural biology is entering a new era. Not just the…
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