SIBYLS beamline scientists Daniel Rosenberg and Michal Hammel collaborated with the Shih Lab at UC Berkeley to study patterns of oligomerization in rubisco, nature’s most abundant carbon-fixing enzyme. By using SEC-SAXS-MALS, they were able to conduct a diversity-driven structural study across extant and ancestral form II rubisco and retrace the evolutionary trajectory taken during the…
Read more
Join us for this 2-day SAXS workshop to be held via zoom during the 2022 ALS User Meeting. Registration is FREE. You will need to register for the ALS User Meeting and select the 13th Annual SIBYLS BioSAXS Workhop/tutorial. In addition, please email Kathryn at kburnett@lbl.gov and let her know you plan to attend (or…
Read more
Our very own James Holton has organized what looks to be a fantastic Gordon Research Conference. Diffraction Methods in Structural Biology will be held in Lewiston Maine on the campus of Bates College, July 24 – 29, 2022. Come join us if you are able. Structural biology is entering a new era. Not just the…
Read more
SIBYLS beamline scientist, Scott Classen, collaborated with ScienceIT consultants Shawfeng Dong and Fengchen Liu to use AutoML machine learning for the LoopDHS project. As part of the effort, IT student intern Jordan Jung developed a training dataset for the model to improve the accuracy. These developments enabled Dr. Classen to develop loopDHS a custom software…
Read more
SIBYLS beamline scientist, Michal Hammel, will lead a workshop on Applications of Small Angle Scattering to Structural Biology at the 2022 ACA in Portland, Oregon on July 29th. Registration is now open.
Analyzing SAXS data collected at SIBYLS beamline 12.3.1, Michal Hammel determined the structural arrangement of the VH and VL domains in the COBRA™ (COnditional Bispecific Redirected Activation) T-cell engagers. The study showed that the structural arrangement of the domains in COBRA is different from the expected yet the stable fold is maintained. Findings provide insights…
Read more
SIBYLS beamline scientists contribute to the discovery of an ancient form of rubisco, the most abundant enzyme on earth and critical to life as we know it. By analyzing SEC-SAXS data collected at 12.3.1, they were able to capture how the enzyme’s structure changes during different states of activity. READ MORE
SIBYLS is excited to announce we have a biochemist postdoc fellow opening. This is a great opportunity to work with experienced and innovative scientists in the field of structural biology. We are looking for someone who wants to develop and apply biology for multi-component biological macromolecules. You will be a part of a team that…
Read more