We are pleased to announce the 5th annual SIBYLS bioSAXS workshop “Frontiers in biological SAXS” Date: October 7-8, 2014 Location: Advance Light Source (ALS) at Lawrence Berkeley National Laboratory , Berkeley, CA Small angle scattering (SAS) is experiencing a dramatic increase in popularity within the structural biology community. The availability of synchrotron radiation, low-noise detectors,…
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A new publication is available that describes practical aspects of collecting High-throughput SAXS data at the SIBYLS beamline, with a focus on challenging low concentration samples. Additional practical advice is laid out with respect to interpreting the resulting data. Dyer KN, Hammel M, Rambo RP, Tsutakawa SE, Rodic I, Classen S, Tainer JA, Hura GL.…
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The SIBYLS beamline was instrumental in providing key structural data for two recent publications exploring the dynamic nature of DNA repair. >The Mre11‐Rad50 complex is highly conserved, yet the mechanisms by which Rad50 ATP‐driven states regulate the sensing, processing and signaling of DNA double‐strand breaks are largely unknown. Here we design structure‐based mutations in Pyrococcus…
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Young researchers are encouraged to apply for the Cancun conference “Dynamic Structures in DNA Damage Responses and Cancer” from the 12-15th February, 2014. We expect that there will be lively discussions on both methods and results during the sessions and good opportunities to interact with top colleagues. To inspire your productive discussions the conference venue…
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Greg Hura and colleagues developed and applied nanogold labels for DNA complexes with proteins examined by small angle X-ray scattering (SAXS) to follow DNA conformations acting in error detection by the mismatch repair (MMR) system in solution. This technique can examine short or long pieces of DNA and in most solution conditions, including those closest…
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We are pleased to announce the [4th annual SIBYLS bioSAXS workshop](/2013_saxs_workshop). Date: October 8-9, 2013 Location: Advance Light Source (ALS) at Lawrence Berkeley National Laboratory , Berkeley, CA The SIBYLS team will host a workshop with strong emphasis on experimental aspects of Small Angle X-ray Scattering techniques in structural biology. The two-day workshop will provide…
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scÅtter 1.7b has been released. scÅtter is JAVA-based software for the analysis of biological SAXS datasets. [DOWNLOAD](/scatter) [instructions and tutorial](http://www.bioisis.net/tutorial) are available on the BIOISIS website.
Several new crystal structures of the 70S ribosome in complex with EFG and non-hydrolyzable GTP analogs have revealed how the ribosome directionally translocates mRNA and the tRNAs through the A, P, and E sites and how specific features of EFG and ribosomal RNA act as pawls to enforce this ratcheting mechanism. The new structures were…
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