We are pleased to announce the [4th annual SIBYLS bioSAXS workshop](/2013_saxs_workshop). Date: October 8-9, 2013 Location: Advance Light Source (ALS) at Lawrence Berkeley National Laboratory , Berkeley, CA The SIBYLS team will host a workshop with strong emphasis on experimental aspects of Small Angle X-ray Scattering techniques in structural biology. The two-day workshop will provide…
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scÅtter 1.7b has been released. scÅtter is JAVA-based software for the analysis of biological SAXS datasets. [DOWNLOAD](/scatter) [instructions and tutorial](http://www.bioisis.net/tutorial) are available on the BIOISIS website.
Several new crystal structures of the 70S ribosome in complex with EFG and non-hydrolyzable GTP analogs have revealed how the ribosome directionally translocates mRNA and the tRNAs through the A, P, and E sites and how specific features of EFG and ribosomal RNA act as pawls to enforce this ratcheting mechanism. The new structures were…
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>*We spent many long nights at the Advanced Light Source, running on coffee, donuts and barbecued ribs from the legendary Everett & Jones BBQ in West Berkeley.* A very interesting historical reflection by Harry Noller entitled “By Ribosome Possessed” has just been published in JBC. It is his personal account of growing up in the…
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SIBYLS scientists have recently published and made available tools for generating [SAXS structural comparison maps](/saxs_similarity “SAXS structural comparison maps”). Details of the methods have been published in Nature Methods. >Biological macromolecular functions require distinct conformational states that are challenging to examine comprehensively. Current methods to quantify conformational similarities and distinguish different assembly states are underdeveloped.…
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Rob and John have a new review on SAXS and its application to systems biology published in the Annual Review of Biophysics. See if you can spot the musical theme. >Small-angle X-ray scattering (SAXS) is a robust technique for the comprehensive structural characterizations of biological macromolecular complexes in solution. Here, we present a coherent synthesis…
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Rob Rambo and John Tainer describe new SAS metrics in a paper titled “Accurate assessment of mass, models and resolution by small-angle scattering.” The paper has been published in the journal Nature. > “In SAS imaging, beams of X-rays or neutrons sent through a sample produce tiny collisions between the X-rays or neutrons and nano-…
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A manuscript highlighting the technical capabilities of the SIBYLS beamline has been published in the Journal of Applied Crystallography: > The SIBYLS beamline (12.3.1) of the Advanced Light Source at Lawrence Berkeley National Laboratory, supported by the US Department of Energy and the National Institutes of Health, is optimized for both small-angle X-ray scattering (SAXS)…
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