Science Highlights

Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor

Apoptosis-inducing factor (AIF) is critical for mitochondrial respiratory complex biogenesis and for mediating necroptotic parthanatos; these functions are seemingly regulated by enigmatic allosteric switching driven by NADH charge-transfer complex (CTC) formation. In this paper the authors define molecular pathways linking AIF’s active site to allosteric switching regions by characterizing dimer-permissive mutants using small-angle X-ray scattering…
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SAXS used to elucidate mechanism of inner-ear mechanotransduction

Tip link filaments convey force and gate inner-ear hair-cell transduction channels to mediate perception of sound and head movements. Cadherin-23 and protocadherin-15 form tip links through a calcium-dependent interaction of their extracellular domains made of multiple extracellular cadherin (EC) repeats. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved…
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7th Annual SIBYLS BioSAXS Workshop a big success

The BioSAXS workshop at the ALS User Meeting on October 4th and 5th was a big success. The workshop was filled to capacity with attendees coming from many different regions of the US. Participants were given detailed information about the range and capabilities of our new Pilatus detector and the future upgrades to the SIBYLS…
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7th Annual SIBYLS BioSAXS workshop 2016

We are pleased to announce the 7th annual SIBYLS bioSAXS workshop: **Date**: October 4th – 5th, 2016 **Location**: Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory, Berkeley, CA **Description**: The 7th annual SIBYLS bioSAXS workshop will cover frontiers in Biological SAXS. The two-day workshop will provide participants with software tutorial sessions for biological SAXS…
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Exploring the Repeat Protein Universe through Computational Protein Design

The facilities and staff at the SYBILS beamline contributed to this breakthrough study exploring the extent to which naturally occurring proteins sample the space of folded structures accessible to the polypeptide chain. Naturally occurring proteins–chains of amino acids that fold into functional, three-dimensional shapes–are believed to represent just a small fraction of the universe of…
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SIBYLS Installs New Dectris Detector

Our new pixel array detector, a [Pilatus3 2M](https://www.dectris.com/PILATUS3_SandX.html#main_head_navigation) from dectris, arrived at LBNL on July 27, 2015 and was installed on the SAXS endstation at SIBYLS beamline 12.3.1. The first user data was collected on August 19, 2015.

2015 SAXS Hands-on Workshop a Success

Our 6th annual SIBYLS bioSAXS workshop “Frontiers in biological SAXS” was a huge success. A big thank you to all of you who attended and a special thanks to our fabulous speakers: – Robert Rambo, Principal Beamline Scientist for the solution state SAXS beamline B21 at the Diamond Light Source, Oxfordshire, UK – John J.…
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Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody

The facilities and staff at the SIBYLS beamline contributed to this recent structural study of a human antibody that is able to neutralize Marburg and Ebola viruses. >The filoviruses, including Marburg and Ebola, express a single glycoprotein on their surface, termed GP, which is responsible for attachment and entry of target cells. Filovirus GPs differ…
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