Central challenges in the design of large and dynamic macromolecular assemblies for synthetic biology lie in developing effective methods for testing design strategies and their outcomes, including comprehensive assessments of solution behavior. The authors of this paper created and validated an advanced design of a 600-kDa protein homododecamer that self-assembles into a symmetric tetrahedral cage.…
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Date: October 2 – 3, 2019 Location: Building 33 at Lawrence Berkeley National Laboratory, Berkeley, CA Building / ROOM : 33-306 This two-day workshop will cover frontiers in biological SAXS and will provide participants with software tutorial sessions for biological SAXS in addition to hands-on training in experimental techniques. The latest advances in SAXS studies…
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** Date: October 3 – 4, 2018 Location: Advanced Light Source at Lawrence Berkeley National Laboratory, Berkeley, CA Building 33 room 306 The two-day workshop, held during [ALS user meeting](https://als.lbl.gov/user-meeting/ “ALS user meeting”), will provide participants with software tutorial sessions for biological SAXS in addition to hands-on training in experimental techniques. The latest advances in…
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We are pleased to announce the 8th annual SIBYLS bioSAXS workshop as part of the Advanced Light Source 2017 User Meeting: Date: October 3 – 4, 2017 Location: Advanced Light Source at Lawrence Berkeley National Laboratory, Berkeley, CA Description: The 8th annual SIBYLS bioSAXS workshop will cover frontiers in Biological SAXS. The two-day workshop will…
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This film was recorded at the International Crystallography Conference, 1965, Melbourne, Australia, by the CSIRO Film Unit in collaboration with the Australian Academy of Science. If you are at all interested in the history of crystallography, and of science in general, I think you will find this video to be 15 well spent minutes. This…
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Are you looking to apply your skills in Integrative Structural Biology to the development of new approaches to explore organization of functional bacterial chromosome? The SIBYLS Group at Lawrence Berkeley National Laboratory is seeking a Biochemist Postdoctoral Fellow in the field of Integrative Structural Biology. For more details on the position and to apply follow…
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SIBYLS has installed new robotics that halve the time it takes to collect a full 96-well plate, from approximately 5 hours to 2.5 hours per plate (with the potential to collect a plate in 10 minutes over the coming year). We believe this will be a game changer for many reasons. We will be able…
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In this paper, the authors show that CRY1, a protein coding gene that activates circadian gene expression and metabolic states and circadian oscillators, binds directly to the PAS domain core of CLOCK:BMAL1. Precise control of CLOCK:BMAL1 activity by coactivators and repressors establishes the ~24 hr periodicity of gene expression. Integrative modeling and solution X-ray scattering…
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